PMID: 6123511Dec 1, 1981Paper

An electropharmacological analyses of the effects of some drugs on neuromuscular transmission in the vas deferens of the guinea-pig

Journal of Autonomic Pharmacology
A G BlakeleyS A Petersen


1 The effects of several drugs upon the excitatory junction potential (e.j.p.) in the guinea-pig vas deferens have been investigated. 2 Amiodarone, a noradrenergic neurone blocker which also blocks both alpha and beta-adrenoreceptors, did not reduce the e.j.p. 3 The alpha-adrenoreceptor antagonists, azapetine, piperoxan and prazosin, only enhanced the e.j.p. irrespective of their relative potencies at alpha 1 and alpha 2-adrenoreceptors. 4 Sotalol, a beta-adrenoreceptor antagonist, was without effect upon the e.j.p. 5 Clonidine and lysergic acid diethylamide, alpha-adrenoreceptor agonists, produced a dose dependent inhibition of the e.j.p. without apparently affecting the frequency or size of spontaneous junction potentials. 6 The effects of clonidine were antagonized by piperoxan in a competitive reversible manner. 7 It is argued that these results confirm the presence of alpha-adrenoreceptors prejunctionally upon the sympathetic excitatory innervation of the vas deferens but that although an endogenous alpha-adrenoreceptor agonist is released by nerve stimulation either the transmitter that is responsible for the e.j.p. is not noradrenaline or that the postjunctional receptors responsible for the generation of the e.j.p. are ...Continue Reading


Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Dec 1, 1977·The Journal of Physiology·P G Anton, J C McGrath
Oct 1, 1977·Physiological Reviews·T C Westfall
Jan 20, 1970·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G BlakeleyV Harrison
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Jul 1, 1971·The Journal of Physiology·N Ambache, M A Zar
Mar 1, 1974·Acta Physiologica Scandinavica·U S von Euler, P Hedqvist
Sep 1, 1967·The Journal of Physiology·C B Ferry
Jan 1, 1961·The Journal of Physiology·G BURNSTOCK, M E HOLMAN
Dec 1, 1961·British Journal of Pharmacology and Chemotherapy·B N DIXITS D GOKHALE
Apr 8, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·C OWMAN, N O SJOESTRAND

❮ Previous
Next ❯


Jan 1, 1990·Annals of the New York Academy of Sciences·J A Brock, T C Cunnane
Jun 1, 1988·Journal of Autonomic Pharmacology·K R Borkowski
Jan 13, 2005·British Journal of Pharmacology·Marco AlvarezJacques M Lignon
Mar 1, 1984·Journal of Autonomic Pharmacology·A G BlakeleyS A Petersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.