PMID: 8584039Sep 1, 1995Paper

An electrophysiological investigation of the effects of cisplatin and the protective actions of dexamethasone on cultured dorsal root ganglion neurones from neonatal rats

Naunyn-Schmiedeberg's Archives of Pharmacology
R H ScottP L Andrews

Abstract

In this study we have investigated the acute and chronic effects of cisplatin on whole cell currents in cultured dorsal root ganglion neurones. Consistent with effects on action potentials measured under current clamp, acute (5 min) application of cisplatin (5 microM) attenuated voltage-activated potassium, and mixed cation currents by approximately 50% in both cases. Chronic treatment (5-7 days) of cultured neurones with 5 microM cisplatin also resulted in greatly reduced voltage-activated potassium currents (by 50%) and calcium currents (by 60%) compared to events recorded from neurones not treated with cisplatin. In contrast, the amplitude of inward cation current activated by hyperpolarization was doubled by 5-12 days treatment with cisplatin. Studies on action potential after-depolarizations and calcium-activated chloride currents suggest that cisplatin disturbs calcium homeostatic mechanisms. These observations may account for anode break spike excitation and the low efficiency with which cells buffer intracellular calcium following cisplatin treatment. Dexamethasone has been found to enhance the anti-emetic effects of 5-HT3 receptor antagonists in patients treated with cisplatin. For this reason the actions of dexamethas...Continue Reading

Citations

Oct 27, 2004·Expert Opinion on Drug Safety·Guido Cavaletti, Paola Marmiroli
May 24, 2008·Toxicology·Hasan MahmudFlorian Lang
Jun 21, 2005·European Journal of Pharmacology·Angie H Y LauDavid T W Yew
Jan 10, 2008·Neuro-degenerative Diseases·B FrickerF René
Sep 3, 2013·Current Opinion in Neurology·Manuel DieziThierry Kuntzer
Jan 8, 2011·Expert Opinion on Drug Safety·David BalayssacNicolas Authier
Feb 20, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Pattarawadee PrayuenyongDavid M Baguley
Aug 13, 2021·Frontiers in Neuroscience·Pattarawadee PrayuenyongPeter S Steyger

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