PMID: 5918062Aug 1, 1966

An electrophysiological study of 5-hydroxytryptamine receptors of neurones in the molluscan nervous system

The Journal of Physiology
H M Gerschenfeld, E Stefani

Abstract

1. 5-Hydroxytryptamine (5-HT) has been iontophoretically applied to the membrane of central neurones of Cryptomphallus aspersa; CILDA neurones (cells with inhibition of long duration) (Gerschenfeld & Tauc, 1964) are the only cells sensitive to 5-HT. The responses to 5-HT is always a depolarization. The CILDA cells studied were also depolarized by ACh.2. From experiments in which pulses of 5-HT and ACh were applied from a double-barrelled micropipette to the CILDA cell soma, it has been calculated that 5-HT and ACh receptors were located at different distances from the injecting micropipette tip. It has also been calculated from the diffusion equation that in the same CILDA cell a 5-HT concentration of 8.2 x 10(-9)M and a ACh concentration of 1.3 x 10(-8)M caused a similar peak depolarization.3. CILDA neurones show ;anomalous' rectification. 5-HT increases the membrane conductance of CILDA.4. 5-HT receptors of CILDA neurone are desensitized by repeated application of 5-HT. The desensitization lasts for ca. 40 sec.5. 5-HT receptors are blocked by lysergic acid diethylamide and its derivatives. Morphine chlorhydrate blocks them non-competitively.6. Some inhibitors of monoamine oxidase (trancylpromine, isocarboxazide, iproniazide a...Continue Reading

Citations

Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-ColungaR Miledi
Nov 15, 1974·Experientia·W D Heiss, J Hoyer
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·P YavariG A Kerkut
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·F Eusebi, P Palmieri
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Jan 1, 1976·Journal of Neural Transmission·W D HeissG Thalhammer
Jan 1, 1984·Progress in Neurobiology·K S Rózsa
Jan 1, 1982·Progress in Neurobiology·R S Jones
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Jan 1, 1990·The European Journal of Neuroscience·Danièle Paupardin-Tritsch, H M Gerschenfeld
Apr 18, 2006·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Pedro Cabral
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Oct 1, 1996·British Journal of Pharmacology·K A GreenG A Cottrell

Related Concepts

Acetylcholine Sulfate (1: 1)
Atropen
Electrophysiology (Science)
Iontophoresis
Lysergic Acid Diethylamide Tartrate
Mollusca
Morphine Sulfate (2: 1), Pentahydrate
Nervous System Structure
Neurons
Sensory Receptor Cells

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