An electrophysiological study of amiloride on sino-atrial node cells and ventricular muscle of rabbit and dog

Naunyn-Schmiedeberg's Archives of Pharmacology
H Satoh, K Hashimoto


Effects of amiloride were studied on canine and rabbit sino-atrial node cells and the canine ventricular cells. In the canine sino-atrial node selectively perfused with Tyrode solution through the sinus node artery, amiloride (4.4 X 10(-4)-1.3 X 10(-2)mol/l) induced a negative chronotropic and a positive inotropic effect in a concentration-dependent manner. In canine ventricular muscle, the amplitude of the action potential and the resting membrane potential were decreased in the presence of amiloride (4.4 X 10(-6)-8.7 X 10(-4) mol/l). The maximum rate of rise was also depressed in a use-dependent manner as well as a concentration-dependent manner. Simultaneously the action potential duration was markedly prolonged. Low concentrations of amiloride decreased the contractile force, but higher concentrations (over 8.7 X 10(-5) mol/l) enhanced it. In the spontaneously beating rabbit sino-atrial node, amiloride (8.7 X 10(-5)-2.2 X 10(-3) mol/l) lengthened the action potential duration and the cycle length accompanied with the decreases in the amplitude and the maximum rate of rise of the action potential. The maximum diastolic potential was slightly depolarized. In voltage clamp experiments of the rabbit sino-atrial node, amiloride ...Continue Reading


Sep 1, 1979·Journal of Cardiovascular Pharmacology·K HashimotoS Imai
Mar 1, 1979·The American Journal of Physiology·L J Mullins
Jan 1, 1978·The Journal of Physiology·T F McDonald, W Trautwein
Jun 29, 1976·Pflügers Archiv : European journal of physiology·A Noma, H Irisawa
Apr 1, 1975·American Heart Journal·R H SellerC Swartz
Sep 1, 1975·Journal of Molecular and Cellular Cardiology·D Kreitner
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·P Heistracher
Jan 1, 1971·Pflügers Archiv : European journal of physiology·R Ochi, W Trautwein
Jan 1, 1969·Biochimica Et Biophysica Acta·W O Kwant, P Seeman
Mar 1, 1968·The Journal of Physiology·P J Bentley
Jul 1, 1981·Journal of Cardiovascular Pharmacology·S YamashitaN Taira
Apr 1, 1984·Japanese Journal of Pharmacology·H Satoh, K Hashimoto
Jan 1, 1983·The American Journal of Physiology·C O Lee, M Vassalle
Apr 1, 1983·Japanese Journal of Pharmacology·H Satoh, K Hashimoto
Oct 15, 1984·European Journal of Pharmacology·M Floreani, S Luciani
Mar 23, 1984·European Journal of Pharmacology·H Satoh, K Hashimoto
Apr 1, 1982·Physiological Reviews·H F Brown
Jan 1, 1980·The Japanese Journal of Physiology·K YanagiharaH Irisawa
Jul 1, 1964·The Journal of Clinical Investigation·L E EARLEY, R M FRIEDLER

❮ Previous
Next ❯


Aug 11, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·L BrownJ R Bourke
Nov 1, 1994·European Journal of Pharmacology·G CargnelliS Luciani
Apr 2, 1998·General Pharmacology·H Satoh, N Sperelakis
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·K P MullM L Bhattacharyya
Jan 22, 1998·Journal of Cardiovascular Pharmacology·H Satoh, M Horie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.