An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338

British Journal of Pharmacology
Yumiko KanemotoYushi Ito

Abstract

1. To study the mechanisms involved in the action of Z-338, a newly synthesized gastroprokinetic agent, experiments were performed with the paratracheal ganglion cells acutely dissociated from 2-week-old Wistar rats. The effects of Z-338 on both nicotinic and muscarinic responses of the ganglion cells were studied by nystatin perforated patch recording configuration under the current- and voltage-clamp conditions. 2. Acetylcholine (ACh) or nicotine, and muscarine or oxotremorine-M (OX-M) induced membrane depolarization with rapid and slow time courses respectively, followed by repetitive generation of action potentials in the ganglion cell. Corresponding to the membrane depolarization induced by cholinergic agents, ACh induced biphasic inward currents with rapid and slow time courses under the voltage-clamp condition. Nicotine and muscarine or OX-M evoked inward currents with rapid and slow time courses, respectively. The rapid and slow inward currents were accompanied by increase and decrease in the membrane conductance, respectively. In addition, OX-M dose-dependently suppressed the M-type K(+) current evoked in response to hyperpolarizing voltage-steps from V(H) of -25 mV to -50 mV, indicating that the activation of muscarin...Continue Reading

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Citations

Jul 25, 2013·Drugs·Mary L NowlanLesley J Scott
Apr 13, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hironari AkaikeNorio Akaike
Jun 3, 2014·Expert Opinion on Drug Metabolism & Toxicology·Yan SunRichard W McCallum
Jul 29, 2016·Neurogenesis·Brent AsricanChay T Kuo
May 6, 2015·Neuropharmacology·Michiko HirayamaHitoshi Ishibashi
Jun 29, 2004·Pulmonary Pharmacology & Therapeutics·K Racké, S Matthiesen
Aug 28, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jian-Rong ZhouKazuo Takahama
Jun 3, 2020·Doklady. Biochemistry and Biophysics·A S PivovarovV I Tsetlin
Oct 22, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hitoshi Ishibashi, Mari Umezu
Dec 1, 2007·Current Protocols in Pharmacology·Allen C Myers
Sep 27, 2008·Brain Research·Sandra RafalzikRüdiger Gerstberger

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