An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Zakir SiddiqueeJames R Stone

Abstract

Recently, it was shown that infectious bacterial aortitis can stimulate an elevated IgG4⁺ plasma cell response in the vessel wall, which could mimic IgG4 aortitis/periaortitis. However, the factors that are associated with an elevated IgG4⁺ plasma cell response in infectious aortitis are unclear. To ascertain these factors, 17 cases of infectious aortitis and 6 cases of non-infectious severe abdominal aortic atherosclerosis were assessed for the magnitude of IgG4⁺ plasma cell response. The degree of IgG4⁺ plasma cell infiltration was determined by immunohistochemistry. Infectious cases were subcharacterized as chronic (>3 weeks duration) or acute (<3 weeks duration) based on the duration of symptoms, and as involving either the ascending aorta or the distal aorta, ie, the descending thoracic and/or abdominal aorta. There was a 5-16-fold greater degree of IgG4⁺ plasma cell infiltration in the chronic distal infectious aortitis group compared with the other three infectious aortitis groups (P ≤ 0.0007), and compared with non-infectious severe abdominal aortic atherosclerosis (P<0.0008). This resulted in a greater IgG4/IgG ratio in the chronic distal infectious aortitis group compared with the acute ascending and acute distal infe...Continue Reading

References

Feb 13, 2004·Mayo Clinic Proceedings·W Darrin ClouseL Joseph Melton
Feb 17, 2009·Journal of Vascular Surgery·Satomi KasashimaFuminori Kasashima
Jul 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeGregory Y Lauwers
Oct 1, 2009·Arthritis and Rheumatism·John H StoneJames R Stone
Aug 4, 2010·Journal of Vascular Surgery·Satomi KasashimaYasuni Nakanuma
Dec 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aiko SakamotoRyozo Nagai
Mar 13, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Zakir SiddiqueeJames R Stone
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeJohn H Stone

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Citations

Jan 15, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Domenico CorradiAugusto Vaglio
Oct 7, 2020·Medicine·Louis JourneauOlivier Espitia

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