An elevated neutrophil-to-lymphocyte ratio predicts a poor postoperative survival in primary hepatocellular carcinoma patients with a normal preoperative serum level of alpha-fetoprotein

Surgery Today
Takayuki ShirakiTaku Aoki

Abstract

Although alpha-fetoprotein (AFP) is a useful prognostic marker in patients with hepatocellular carcinoma (HCC), a recent study has shown that the preoperative neutrophil-to-lymphocyte ratio (NLR) is also associated with the postoperative survival in such patients. To investigate the significance of the NLR in patients with primary HCC (p-HCC) showing a normal preoperative AFP. Among 478 p-HCC patients undergoing curative surgery, 112 who had a normal AFP (< 8 ng/ml) were enrolled. The patients were divided into two groups: group A, who did not have an elevated NLR (≤ 3.2); and group B, who had an elevated NLR (> 3.2). Uni- and multivariate analyses were performed to compare clinical features with the overall survival (OS). A multivariate analysis of the clinical features showed that the NLR (> 3.2/≤ 3.2) (hazard ratio 2.366; 95% CI 1.069-5.235; P = 0.034) was closely associated with the OS, along with the age (> 65/≤ 65 years) (P = 0.033). Group B had a significantly lower survival ratio than group A in terms of not only the OS (P = 0.013), but also the cancer-specific survival (P = 0.002) and relapse-free survival (P = 0.039). An elevated NLR (> 3.2) is predictive of a poor survival in patients with primary HCC (p-HCC) showing...Continue Reading

References

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Oct 28, 2003·Annals of Surgery·Masami MinagawaNorihiro Kokudo
Jan 1, 1950·Cancer·W J YOUDEN
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuji Seyama, Norihiro Kokudo
May 25, 2012·Journal of Surgical Oncology·Mitsuru IshizukaKeiichi Kubota
Apr 23, 2013·Critical Reviews in Oncology/hematology·Graeme J K GuthrieStephen J Clarke
Nov 28, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W FaberD Seehofer
May 20, 2015·World Journal of Gastroenterology : WJG·Hao DuanPeng Lin

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