An elevation in the concentration of HLA class I molecules in human blood due to ageing

Mechanisms of Ageing and Development
C Le MorvanM Drouet

Abstract

The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The variation of sHLA-I content could contribute to the unresponsiveness of ageing immune system.

References

Jan 1, 1989·Vox Sanguinis·I Doxiadis, H Grosse-Wilde
Nov 1, 1989·Journal of Gerontology·D SegreH R Warner
Apr 25, 1970·Nature·J J van RoodM C van Santen
Nov 1, 1984·Mechanisms of Ageing and Development·G J LigthartG G Steinmann
Sep 1, 1995·Immunology Today·G PawelecK Schaudt
Oct 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M DrouetR Fauchet
Jul 31, 1998·Human Immunology·J C McDonald, I Adamashvili
Dec 23, 1998·Mechanisms of Ageing and Development·C Le MorvanM Drouet

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