An EM algorithm for estimating SPECT emission and transmission parameters from emissions data only

IEEE Transactions on Medical Imaging
A KrolF D Thomas

Abstract

A maximum-likelihood (ML) expectation-maximization (EM) algorithm (called EM-IntraSPECT) is presented for simultaneously estimating single photon emission computed tomography (SPECT) emission and attenuation parameters from emission data alone. The algorithm uses the activity within the patient as transmission tomography sources, with which attenuation coefficients can be estimated. For this initial study, EM-IntraSPECT was tested on computer-simulated attenuation and emission maps representing a simplified human thorax as well as on SPECT data obtained from a physical phantom. Two evaluations were performed. First, to corroborate the idea of reconstructing attenuation parameters from emission data, attenuation parameters (mu) were estimated with the emission intensities (lambda) fixed at their true values. Accurate reconstructions of attenuation parameters were obtained. Second, emission parameters lambda and attenuation parameters mu were simultaneously estimated from the emission data alone. In this case there was crosstalk between estimates of lambda and mu and final estimates of lambda and mu depended on initial values. Estimates degraded significantly as the support extended out farther from the body, and an explanation f...Continue Reading

References

Aug 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J Van DykW D Rider
Jul 1, 1995·Physics in Medicine and Biology·S H ManglosR Narayanaswamy
Jan 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M A KingE J Soares
Jul 1, 1996·Medical Physics·M S KaplanT K Lewellen
Sep 1, 1996·Physics in Medicine and Biology·E U MumcuoğluS R Cherry
Apr 1, 1997·IEEE Transactions on Medical Imaging·J A FesslerK Lange
Nov 22, 1997·IEEE Transactions on Medical Imaging·A WelchG T Gullberg
Nov 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M A KingT S Pan
Oct 31, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B M TsuiG T Gullberg
Mar 10, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J R Corbett, E P Ficaro
Feb 24, 2001·IEEE Transactions on Medical Imaging·D F YuE P Ficaro
Jan 1, 1996·IEEE Transactions on Medical Imaging·J E BowsherR E Coleman
Jan 1, 1994·IEEE Transactions on Medical Imaging·H M Hudson, R S Larkin
Jan 1, 1990·IEEE Transactions on Medical Imaging·P J Green
Jan 1, 1990·IEEE Transactions on Medical Imaging·K Lange
Jan 1, 1987·IEEE Transactions on Medical Imaging·K LangeR Little
Jan 1, 1989·IEEE Transactions on Medical Imaging·T Hebert, R Leahy
Jan 1, 1982·IEEE Transactions on Medical Imaging·L A Shepp, Y Vardi
Jan 1, 1996·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·C A Bouman, K Sauer
Jan 1, 1995·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·K Lange, J A Fessler

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Citations

Feb 5, 2016·Medical Physics·Yannick Berker, Yusheng Li
Feb 12, 2010·International Journal of Imaging Systems and Technology·Yan Yan, Gengsheng Lawrence Zeng
Mar 15, 2015·IEEE Transactions on Medical Imaging·Abolfazl Mehranian, Habib Zaidi
Apr 25, 2014·IEEE Transactions on Medical Imaging·Ahmadreza RezaeiJohan Nuyts
Sep 28, 2012·IEEE Transactions on Medical Imaging·Johan NuytsCharles Watson
Aug 18, 2012·IEEE Transactions on Medical Imaging·Ahmadreza RezaeiJohan Nuyts
Nov 8, 2013·IEEE Journal of Selected Topics in Signal Processing·Charles M Laymon, James E Bowsher
Dec 2, 2010·IEEE Transactions on Medical Imaging·André SalomonVolkmar Schulz
Jan 22, 2004·Zeitschrift für medizinische Physik·Michael Landmann, Gerhard Glatting
Sep 1, 2016·IEEE Transactions on Medical Imaging·Alexander Mihlin, Craig S Levin
Feb 8, 2014·Physics in Medicine and Biology·Michel DefriseJohan Nuyts
Jun 6, 2015·Physics in Medicine and Biology·Abolfazl Mehranian, Habib Zaidi
Oct 24, 2018·Annals of Nuclear Medicine·Getu Ferenji TadesseMohammad Reza Ay
Feb 1, 2012·Physics in Medicine and Biology·Michel DefriseJohan Nuyts
Dec 3, 2016·Physics in Medicine and Biology·Didier BenoitJohan Nuyts
Mar 29, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Luyao ShiChi Liu

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