An emerging integration between ionic liquids and nanotechnology: general uses and future prospects in drug delivery

Therapeutic Delivery
Tânia Santos de AlmeidaCatarina Pinto Reis

Abstract

There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects. This overview on the properties of ILs, NPs and of their combined structures, reveals the recent advances in these areas through a review of pertinent literature. The IL-NP structures present enhanced properties and the subsequent performance upgrade proves to be useful in drug delivery, although much is yet to be done.

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Citations

Sep 3, 2020·International Journal of Molecular Sciences·Jolanta Flieger, Michał Flieger
Nov 11, 2020·International Journal of Molecular Sciences·Sónia N PedroMara G Freire
Feb 8, 2021·Drug Discovery Today·Manuel SimõesFernanda Borges
Dec 29, 2020·Nanomedicine·Mariana AmaralCatarina Pinto Reis
Oct 1, 2020·Analytica Chimica Acta·Ana M O AzevedoM Lúcia M F S Saraiva
Jul 11, 2021·Advanced Science·Alexander M CurreriEden E L Tanner
Aug 29, 2021·Pharmaceutics·Ana JúlioTânia Santos de Almeida

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Methods Mentioned

BETA
scanning electron microscopy

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