An emerging role for calcineurin Aalpha in the development and function of the kidney

American Journal of Physiology. Renal Physiology
Jennifer L Gooch

Abstract

For many years, calcineurin has been a familiar molecule as a target of the immunosuppressive agents cyclosporin A and FK-506. Calcineurin inhibition interferes with T cell signaling by preventing activation of the transcription factor NFATc. However, calcineurin is expressed in most tissues in the body, and calcineurin inhibition undoubtedly alters many other cellular processes. As a result, serious side effects of calcineurin inhibitors regularly occur, including hypertension and renal dysfunction. Because nephrotoxicity is often a barrier to continued clinical use of calcineurin inhibitors, understanding the role of calcineurin in the kidney is of particular importance. Recent work has demonstrated that the two main isoforms of the catalytic subunit of calcineurin, Aalpha and Abeta, may have distinct functions, particularly in the kidney. Calcineurin isoforms may be differentially expressed, and/or the activity of each may be differentially regulated, leading to tissue-specific functions. Differences between the action of the two isoforms are most evident in knockout mice lacking each isoform. Mice lacking the beta-isoform are characterized principally by altered development and function of immune cells. alpha-Knockout mice,...Continue Reading

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Citations

Jul 19, 2012·Expert Reviews in Molecular Medicine·Clintoria R Williams, Jennifer L Gooch
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Yan ZhangWen-Hui Wang
Jan 9, 2009·American Journal of Physiology. Renal Physiology·Fiona M KellyJennifer L Gooch
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Feb 15, 2008·American Journal of Physiology. Renal Physiology·Seon-Young KimUh-Hyun Kim
Sep 26, 2009·Journal of Cellular and Molecular Medicine·Ramesh N ReddyJennifer L Gooch
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Nov 24, 2020·American Journal of Physiology. Renal Physiology·Adaku C UmeClintoria R Williams
Mar 25, 2021·Bulletin of Environmental Contamination and Toxicology·Changzhong LiWenjie Jin
Feb 23, 2021·American Journal of Physiology. Renal Physiology·Aswathy M CheriyanClintoria R Williams

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