An emerging role for nuclear RNA-mediated responses to genotoxic stress.

RNA Biology
Roberta Busà, Claudio Sette

Abstract

Defects in the regulation of alternative splicing have strong relevance in the onset and progression of several types of human cancer. Modulation of alternative splicing allows cancer cells to adapt to hostile environments through production of specific mRNA variants. In particular, genotoxic stress exerted by chemotherapeutic drugs or irradiation strongly affects splicing of many genes. A key role in this aberrant regulation is played by the unbalanced expression of several splicing factors in cancer cells. Among them, the RNA-binding protein Sam68, which is overexpressed in various tumors, was shown to accumulate in nuclear foci of active transcription, together with other splicing regulators, and to affect splicing of target mRNAs in response to genotoxic stress. We suggest that subcellular redistribution of splicing factors is guided by changes in chromatin conformation elicited by DNA-damaging drugs. This event might represent an escape mechanism used by cancer cells to survive to genotoxic insults through expression of pro-survival, cancer-specific gene products.

References

Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·A E McBrideK Kirkegaard
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·D A RockxL H Mullenders
Sep 26, 2001·The Journal of Biological Chemistry·S BurmaD J Chen
Jul 12, 2002·Nature·Tom Maniatis, Bosiljka Tasic
Dec 13, 2002·Nature·Nathalie MatterHarald König
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Mar 11, 2003·Annual Review of Biochemistry·Douglas L Black
Oct 11, 2003·Molecular Cell·Manuel de la MataAlberto R Kornblihtt
Dec 4, 2003·Biochimica Et Biophysica Acta·Kiven E Lukong, Stéphane Richard
Mar 25, 2004·The American Journal of Pathology·Maria Paola ParonettoClaudio Sette
Feb 11, 2005·Nucleic Acids Research·Suhasini ModemThipparthi R Reddy
Mar 25, 2005·Molecular Biology of the Cell·Rut ValgardsdottirGiuseppe Biamonti
Sep 24, 2005·The Journal of Biological Chemistry·Kiven Erique LukongStéphane Richard
Dec 13, 2005·Nature Structural & Molecular Biology·Eric BatschéChristian Muchardt
Dec 16, 2005·Molecular and Cellular Biology·Chonghui Cheng, Phillip A Sharp
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Craig J BurdKaren E Knudsen
Mar 21, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Julian P Venables
Apr 13, 2006·BMC Bioinformatics·Chaolin ZhangMichael Q Zhang
Jul 19, 2006·Molecular and Cellular Biology·Sonia GuilJavier F Cáceres
Nov 3, 2006·Genes & Development·Hemali P Phatnani, Arno L Greenleaf
Feb 21, 2007·Nature Structural & Molecular Biology·Rotem KarniAdrian R Krainer
Mar 21, 2007·The Journal of Cell Biology·Maria Paola ParonettoClaudio Sette
Aug 30, 2007·Nature Reviews. Genetics·Guey-Shin Wang, Thomas A Cooper
Sep 27, 2007·Nature Reviews. Neuroscience·Qin LiDouglas L Black
Oct 12, 2007·Future Oncology·Kiven E Lukong, Stéphane Richard
Nov 28, 2007·Nucleic Acids Research·Rut ValgardsdottirGiuseppe Biamonti
Dec 7, 2007·Trends in Genetics : TIG·Eddo KimGil Ast
Feb 5, 2008·Cancer Research·Roscoe KlinckSherif Abou Elela
Feb 23, 2008·Trends in Biochemical Sciences·Paul Anderson, Nancy Kedersha
Mar 29, 2008·PLoS Computational Biology·William RitchieDaniel Gautheret
Jun 21, 2008·Molecular Cancer Therapeutics·Lulzim ShkretaBenoit Chabot
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kazuo FushimiJane Y Wu
Oct 11, 2008·EMBO Reports·Ana Rita GrossoMaria Carmo-Fonseca
Oct 15, 2008·Molecular Cell·Sophie BonnalJuan Valcárcel
Nov 4, 2008·Nature·Eric T WangChristopher B Burge

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Citations

Oct 11, 2011·Nucleic Acids Research·Simona PedrottiClaudio Sette
Sep 25, 2012·Nucleic Acids Research·Yuval NevoRuth Sperling
Nov 4, 2015·Biomolecules·Lulzim Shkreta, Benoit Chabot
Dec 26, 2015·International Journal of Molecular Sciences·Mehmet YabasGerard F Hoyne
Aug 21, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jessica A WarnsArchana Dhasarathy
Aug 15, 2015·BioMed Research International·Paola FrisoneMaria Paola Paronetto
May 14, 2011·Endocrine-related Cancer·Pamela BielliClaudio Sette

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