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An empirical evaluation of the common disease-common variant hypothesis

BMC Proceedings

May 10, 2008

Gary K ChenJohn S Witte

PMID: 18466549

Abstract

While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common variants of modest effects that underlie common disorders. To this end, we were interested in dete...read more

Mentioned in this Paper

Genome-Wide Association Study
Genetic Analysis
Genetic Screening Method
Gene Expression
Nucleotides
Metaplastic Cell Transformation
Alleles
Genetic Polymorphism
Single Nucleotide Polymorphism
Genetic Linkage
Paper Details
References
  • References4
  • Citations1
1
  • References4
  • Citations1
1

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An empirical evaluation of the common disease-common variant hypothesis

BMC Proceedings

May 10, 2008

Gary K ChenJohn S Witte

PMID: 18466549

DOI:

Abstract

While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common variants of modest effects that underlie common disorders. To this end, we were interested in dete...read more

Mentioned in this Paper

Genome-Wide Association Study
Genetic Analysis
Genetic Screening Method
Gene Expression
Nucleotides
Metaplastic Cell Transformation
Alleles
Genetic Polymorphism
Single Nucleotide Polymorphism
Genetic Linkage

Related Papers

La Revue de médecine interne

Childhood-onset systemic lupus erythematosus: polygenic or monogenic disorder?

La Revue de médecine interneDecember 1, 2012
B Bader-MeunierF Rieux-Laucat
Paper Details
References
  • References4
  • Citations1
1
  • References4
  • Citations1
1
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