An Empirical Study of Two Alternative Comparators for Use in Time Trade-Off Studies

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Koonal ShahM F Janssen

Abstract

Studies to produce value sets for preference-based measures of health require definition of a full health upper anchor if the values are to be used to calculate quality-adjusted life years. Recent value sets derived for the EQ-5D-5L instrument have described the upper anchor as "full health," whereas older valuation studies for the EQ-5D used "best health state" in the descriptive system (11111). It is unclear whether this change could have led to differences in the values obtained. The objective of this study was to assess differences in time trade-off (TTO) valuations using two different comparators (full health and 11111). Preferences for EQ-5D-5L health states were elicited from a broadly representative sample of the UK general public. TTO data were collected by using computer-assisted personal interviews. Respondents were randomly allocated to one of two arms, each using a different comparator health state. Respondents completed 10 or 11 TTO valuations and a series of follow-up questions examining their interpretations of the term "full health." Interviews with 443 respondents were completed in 2014. The differences in mean values across arms are mostly small and nonsignificant. The two arms produced data of similar qualit...Continue Reading

References

Nov 21, 1997·Medical Care·P Dolan
Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
Jan 4, 2006·Health Economics·Angela Robinson, Anne Spencer
Apr 12, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M HerdmanX Badia
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·John F P BridgesJosephine Mauskopf
Aug 9, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Bas M F JanssenElly A Stolk
Aug 9, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Koonal K ShahNancy J Devlin
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Mark OppeFrank de Charro
Dec 19, 2014·Medical Care·Juan M Ramos-GoñiOliver Rivero-Arias
Aug 28, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Takeru ShiroiwaKojiro Shimozuma

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Citations

Apr 17, 2016·PharmacoEconomics·Mark OppeNan Luo
Oct 12, 2017·The Patient·Eliza L Y WongOliver Rivero-Arias
Nov 8, 2018·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Ernest H LawAlan Schwartz
Aug 3, 2018·Health and Quality of Life Outcomes·Manuel HuberReiner Leidl
Nov 5, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Christina-Jane Crossman-BarnesGarry Barton
Jun 20, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Anna K Lugnér, Paul F M Krabbe
Apr 12, 2019·Health and Quality of Life Outcomes·Christina-Jane Crossman-BarnesGarry Barton
Mar 19, 2021·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David J MottOliver Rivero-Arias
Jul 25, 2021·International Journal of Environmental Research and Public Health·Marian Sorin PaveliuLuke Vale

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