An Empirical Validation of the Within-subject Biospecimens Pooling Approach to Minimize Exposure Misclassification in Biomarker-based Studies

Epidemiology
Céline VernetRémy Slama

Abstract

Within-subject biospecimens pooling can theoretically reduce bias in dose-response functions from biomarker-based studies when exposure assessment suffers from classical-type error. However, collecting many urine voids each day is cumbersome. We evaluated the empirical validity of a within-subject pooling approach and compared several options to avoid sampling each void. In 16 pregnant women who collected a spot of each urine void over several nonconsecutive weeks, we compared concentrations of 10 phenols in daily, weekly, and pregnancy within-subject pools. We pooled either three or all daily samples. In a simulation study using these data, we quantified bias in dose-response functions when using one to 20 urine samples per subject to assess methylparaben (a compound with moderate within-subject variability) and bisphenol A (high variability) exposures. Correlations between exposure estimates from pools of all and of only three voids per day were above 0.80 for all time windows and compounds, except for benzophenone-3 and triclosan in the daily time window (correlations, 0.57-0.68). With one spot sample to assess pregnancy exposure, correlations were all below 0.74. Using only one biospecimen led to attenuation bias in the dos...Continue Reading

References

May 1, 1987·American Journal of Epidemiology·B BrunekreefP Clausing
Apr 1, 1995·Environmental Health Perspectives·S M RappaportL L Kupper
Jun 1, 1995·Environmental Health Perspectives·R H OlsenA M Byrne
Jan 1, 1997·Epidemiology·E TielemansD F Habbema
Sep 29, 1999·Statistical Methods in Medical Research·J M Bland, D G Altman
Jul 7, 2007·Journal of Biopharmaceutical Statistics·J Martin Bland, Douglas G Altman
Sep 11, 2008·Paediatric and Perinatal Epidemiology·Enrique F Schisterman, Albert Vexler
Jan 6, 2010·Statistics in Medicine·Enrique F SchistermanNeil J Perkins
Jan 6, 2011·Environmental Health Perspectives·Joe M BraunBruce P Lanphear
Jan 21, 2012·Environmental Health Perspectives·Joe M BraunRuss Hauser
Sep 13, 2012·Statistics in Medicine·Enrique F Schisterman, Paul S Albert
Mar 13, 2014·Environmental Health Perspectives·Martine VrijheidMark J Nieuwenhuijsen
Apr 17, 2014·Journal of Exposure Science & Environmental Epidemiology·Todd A JuskoMatthew P Longnecker
Jul 2, 2015·Environmental Health Perspectives·Antonia M CalafatMary S Wolff
Apr 13, 2017·Environmental Health : a Global Access Science Source·Megan E RomanoJoseph M Braun

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Citations

Mar 14, 2020·International Journal of Epidemiology·Lydiane AgierRémy Slama
Sep 26, 2019·Journal of Epidemiology and Community Health·Jana Klánová, Robert Barouki
Jun 11, 2020·Environmental Health : a Global Access Science Source·Vicente Mustieles, Mariana F Fernández
Jul 28, 2020·Environmental Health Perspectives·Michiel A van den DriesAnjoeka Pronk
Oct 17, 2019·International Journal of Environmental Research and Public Health·Sarah Lyon-CaenThe Sepages Study Group
Mar 30, 2020·European Journal of Epidemiology·Susana SantosMartine Vrijheid
Oct 6, 2020·Environmental Pollution·Celine GysAdrian Covaci
Oct 7, 2020·Environmental Research·Claire Philippat, Antonia M Calafat
Mar 1, 2021·Environment International·Yu ZhangCarmen Messerlian
Mar 14, 2021·Environmental Health : a Global Access Science Source·Julie Bang HansenTina Kold Jensen
Jun 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raquel LinaresRubén Francés
Apr 7, 2020·Chemical Research in Toxicology·Rex E FitzGerald

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