PMID: 2504616Sep 1, 1989Paper

An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats

Experimental Neurology
S R WinnP Aebischer

Abstract

The effect of sustained intrastriatal release of dopamine (DA) from polymer matrices on apomorphine-induced turning behavior in a 6-hydroxydopamine (6-OHDA) unilaterally lesioned rat model was analyzed. A biocompatible semipermeable tube was placed in a denervated striatum as a receptacle for DA-releasing polymer rods. In vitro kinetics showed sustained release of DA from a polymeric rod for 15 days. Implantation of a DA-releasing rod within the striatal receptacle significantly decreased apomorphine-induced rotational behaviour in lesioned animals. Upon removal of the DA-releasing system from the receptacle, rotational behaviour increased within 2 weeks and approached preimplant control values 4 weeks later. Acute microdialysis revealed that DA appeared in the extracellular space within 20 min after the implantation of a DA-releasing rod into a denervated striatum. Significant DA amounts were still measurable 7 days postimplantation, indicating sustained DA release from the polymer rod. Dopamine released from a polymer matrix through a semipermeable receptacle alleviates experimental parkinsonism in rats, suggesting that controlled intrastriatal release of DA from a polymer matrix may provide an alternative method for the trea...Continue Reading

Citations

Dec 18, 2001·Biotechnology and Bioengineering·A V AnilkumarT G Wang
Sep 1, 1994·Journal of Biomedical Materials Research·P MeneiJ P Benoit
Mar 1, 1991·Journal of Cellular Biochemistry·W J FreedE I Ginns
Dec 1, 1994·Journal of Neurology·S B Dunnett
Nov 1, 1995·Journal of Neuro-oncology·M MakW M Saltzman
Jan 1, 1996·Acta neurochirurgica·L U WahlbergJ Boëthius
Nov 1, 1990·Biomaterials·M L RadomskyW M Saltzman
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J P BenoitP Menei
Aug 16, 2000·Advanced Drug Delivery Reviews·H UludagP A Tresco
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C BarsoumP L Chang
Mar 31, 2010·Journal of Applied Measurement·Ulrich Müller, Willis F Overton
Apr 17, 2001·Tissue Engineering·S P Baldwin, W M Saltzman
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Young-Tae KimPatrick A Tresco
Oct 12, 2004·Experimental Neurology·Kevin J Whittlesey, Lonnie D Shea
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·D F EmerichP R Sanberg
Jul 1, 1995·Journal of Microencapsulation·J Filipović-GrcićI Jalsenjak
Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Betül AricaA Atilla Hincal
May 20, 1996·Biotechnology and Bioengineering·R H LiF T Gentile
May 20, 1996·Biotechnology and Bioengineering·M S ShoichetS R Winn
Apr 1, 1993·Reviews in the Neurosciences·R Barker, S Dunnett
Dec 17, 1997·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·V MehtaI Mendez

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