An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague.

PLoS Neglected Tropical Diseases
A DerbiseChristian E Demeure

Abstract

Plague is still a public health problem in the world and is re-emerging, but no efficient vaccine is available. We previously reported that oral inoculation of a live attenuated Yersinia pseudotuberculosis, the recent ancestor of Yersinia pestis, provided protection against bubonic plague. However, the strain poorly protected against pneumonic plague, the most deadly and contagious form of the disease, and was not genetically defined. The sequenced Y. pseudotuberculosis IP32953 has been irreversibly attenuated by deletion of genes encoding three essential virulence factors. An encapsulated Y. pseudotuberculosis was generated by cloning the Y. pestis F1-encoding caf operon and expressing it in the attenuated strain. The new V674pF1 strain produced the F1 capsule in vitro and in vivo. Oral inoculation of V674pF1 allowed the colonization of the gut without lesions to Peyer's patches and the spleen. Vaccination induced both humoral and cellular components of immunity, at the systemic (IgG and Th1 cells) and the mucosal levels (IgA and Th17 cells). A single oral dose conferred 100% protection against a lethal pneumonic plague challenge (33×LD(50) of the fully virulent Y. pestis CO92 strain) and 94% against a high challenge dose (3,3...Continue Reading

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Citations

Apr 6, 2016·Chemico-biological Interactions·Christian E DemeureElisabeth Carniel
Mar 7, 2014·International Journal of Medical Microbiology : IJMM·Cyril SavinElisabeth Carniel
Jun 7, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yujun CuiYajun Song
May 13, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Julia M Riehm, Thomas Löscher
Oct 17, 2015·PLoS Neglected Tropical Diseases·Anne DerbiseChristian E Demeure
Mar 23, 2017·The Journal of Veterinary Medical Science·Kosuke TsugoYumi Une
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Oct 6, 2021·PLoS Neglected Tropical Diseases·Guillain MikatyElisabeth Carniel

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Methods Mentioned

BETA
PCR
ELISA
lavage
bronchoalveolar lavage
lavages
bronchoalveolar lavages

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