An endogenous 5-HT(7) receptor mediates pigment granule dispersion in Xenopus laevis melanophores

British Journal of Pharmacology
M T Teh, D Sugden

Abstract

Melatonin (5-methoxy N-acetyltryptamine) and serotonin (5-HT) exert rapid, but opposite effects on pigment granule distribution in Xenopus laevis melanophores. Low concentrations of melatonin (10(-11) - 10(-9) M) cause a dramatic perinuclear aggregation of the melanin-containing granules, while 5-HT (10(-8) - 10(-5) M) disperses pigment granules throughout the cell. The present study found that pharmacological doses of melatonin (> or =10(-6) M) induced a time- and concentration-dependent pigment granule dispersion, which was mediated by an endogenous melanophore 5-HT receptor. 5-HT produced a concentration-dependent elevation of melanophore cyclic AMP, and 5-HT-induced dispersion was blocked by H89 (10(-4) M), an inhibitor of protein kinase A (PKA), but not by a PKC inhibitor (Ro 31-8220, 10(-5) M), indicating a vital role for cyclic AMP in 5-HT-induced dispersion. 5-HT-mediated dispersion was not blocked by antagonists selective for G(s)-coupled 5-HT(4) (GR113808) or 5-HT(6) (Ro 04-6790, Ro 63-0563, olanzepine) receptors, nor by 5-HT(1 - 3) (pindolol, ketanserine, metoclopramide, MDL72222, tropisetron) receptor antagonists, but was inhibited by a selective 5-HT(7) receptor antagonist, DR4004, and other antagonists with a high...Continue Reading

References

Feb 1, 1992·Pharmacology, Biochemistry, and Behavior·B Guardiola-LemaîtreR D Porsolt
Nov 27, 1991·Biochemical and Biophysical Research Communications·P Dieter, E Fitzke
Jan 1, 1990·Pigment Cell Research·A DaniolosM R Lerner
Jan 1, 1990·Psychopharmacology·F WaldhauserI Trinchard-Lugan
Oct 15, 1989·Experientia·D Sugden
Mar 30, 1983·Toxicology and Applied Pharmacology·B N GuptaJ K Haseman
May 1, 1982·British Journal of Pharmacology·S W Holmes, D Sugden
Apr 26, 1995·Biochimica Et Biophysica Acta·A G BlomqvistG J Martens
Jul 1, 1994·Trends in Pharmacological Sciences·P Seeman, H H Van Tol
Jan 1, 1994·British Journal of Pharmacology·J D GaleP P Humphrey
Jan 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·M N Potenza, M R Lerner
Apr 1, 1997·Trends in Pharmacological Sciences·R M EglenG R Martin
Nov 5, 1997·European Journal of Pharmacology·C C Gerhardt, H van Heerikhuizen
Sep 24, 1998·Trends in Pharmacological Sciences·P R SaxenaC M Villalón
Mar 2, 1999·British Journal of Pharmacology·M HemedahF J Mitchelson
Mar 3, 1999·Journal of Medicinal Chemistry·C KikuchiM Koyama
Jul 13, 1999·British Journal of Pharmacology·J A Terrón, A Falcón-Neri
Jul 27, 1999·The Journal of Biological Chemistry·J A RothM I Cho
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K KräuchiA Wirz-Justice
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

❮ Previous
Next ❯

Citations

Aug 20, 2014·Journal of Receptor and Signal Transduction Research·Mohd OvaisMuhammad Mubashshir
Apr 24, 2012·Gene·Henning SchneiderEric Hawley
Feb 27, 2008·Journal of Pineal Research·Simon P FisherDavid Sugden
Jan 13, 2011·Cellular & Molecular Biology Letters·Saima Salim, Sharique A Ali
Mar 15, 2013·Neurochemistry International·Adam Michael StewartAllan V Kalueff
Sep 25, 2010·Journal of Receptor and Signal Transduction Research·Tahira Sultan, Sharique A Ali
Jan 22, 2019·ACS Sensors·Antonella LauriGil G Westmeyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.