PMID: 8601610Apr 1, 1996Paper

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

The Journal of Cell Biology
F AnientoJ Gruenberg

Abstract

In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor.

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Citations

Nov 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Storrie, M Desjardins
Apr 4, 1998·Electrophoresis·M RojoJ Gruenberg
Aug 15, 2002·Cell Biology International·Valérie DardalhonJosette Sainte-Marie
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Dec 23, 2009·Nature·Renate KönigSumit K Chanda
Feb 2, 2006·Nature Cell Biology·Chiara Recchi, Philippe Chavrier
Jun 14, 2005·Nature Cell Biology·Isabelle Le BlancJ Gruenberg
Jan 18, 2006·Nature Cell Biology·Andrés Hurtado-LorenzoVladimir Marshansky
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