PMID: 9548266Apr 21, 1998Paper

An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats

Liver
Chandrashekhar R GandhiVladimir M Subbotin

Abstract

Hepatic levels of a powerful vasoconstrictor endothelin-1 (ET-1) and its receptors increase in human and carbon tetrachloride (CCl4)-induced liver cirrhosis. The aim of this study was to determine whether antagonism of hepatic ET-1 receptors ameliorates CCl4-induced hepatic injury and portal hypertension in rats. Acute liver injury was induced by a single intraperitoneal injection of CCl4 (0.3 ml/kg), whereas cirrhosis and portal hypertension were induced by CCl4 treatment (0.15 ml/kg twice a week) for 8 weeks. Hepatic morphology, ET-1 and its receptors, and portal venous pressures were determined. Increases in ET-1 and its receptors occurred within 24 h of CCl4 administration, and progressively thereafter during the development of cirrhosis. The acute CCl4-induced hepatic injury was characterized by significant increases in portal pressure (from 8.7+/-1.8 to 17.6+/-3.3 mmHg; p<0.01) and serum levels of liver enzymes, as well as massive hepatocellular necrosis (62+/-8%). Intravenous administration of an ET-1 receptor antagonist TAK-044 reduced portal pressure to 13.6+/-2.8 mmHg (p<0.05), and ameliorated hepatocellular necrosis by about 35% (p<0.001). TAK-044 treatment also produced significant reduction in serum levels of liver...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·R B JohnstonZ A Cohn
Jan 1, 1975·The Journal of Experimental Medicine·D B Drath, M L Karnovsky
Jan 1, 1992·Life Sciences·T KuriharaY Hirayama
Dec 17, 1992·The New England Journal of Medicine·K MooreK Badr
Mar 25, 1991·Biochemical and Biophysical Research Communications·D L WilliamsB V Clineschmidt
Aug 29, 1989·European Journal of Pharmacology·D R MorelJ M Lundberg
Jan 1, 1986·Tissue & Cell·D E Sims
Jan 1, 1982·Advances in Experimental Medicine and Biology·F RossiG Zabucchi
Jan 1, 1982·Advances in Experimental Medicine and Biology·M Markert, J Frei
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SakamotoK Tanikawa
Feb 15, 1995·Biochemical and Biophysical Research Communications·D C Rockey
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GotoH Fusamoto
Jan 1, 1993·Gynecologic and Obstetric Investigation·A HalimT Terao
Aug 15, 1993·Archives of Biochemistry and Biophysics·C R GandhiM S Olson
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E BluhmK F Badr
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C HoussetD M Bissell
Mar 8, 1993·FEBS Letters·T A Tran-ThiK Decker
Apr 1, 1993·The Journal of Clinical Investigation·M OshitaH Fusamoto
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C Rockey, R A Weisiger
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y KitayamaE Okamoto
Sep 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C R GandhiJ Fung

❮ Previous
Next ❯

Citations

Sep 15, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·L RothermundB Hocher
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Kristin AnselmiChandrashekhar R Gandhi
Apr 17, 2004·European Journal of Clinical Investigation·C-C ChanS-D Lee
Sep 17, 2008·Journal of Cellular Physiology·Noor Mohamed JameelChandrashekhar R Gandhi
Dec 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Denada DibraShulin Li
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ahmed Helmy, Peter C Hayes
Jun 19, 2003·British Journal of Pharmacology·Xuedong ChiChandrashekhar R Gandhi
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chinnasamy ThirunavukkarasuChandrashekhar R Gandhi
Jan 12, 2008·World Journal of Gastroenterology : WJG·Yan ChenYong-Ping Yang
May 24, 2006·The Journal of Gene Medicine·Vladimir G BudkerJon A Wolff
Jun 17, 2003·Molecular Biology of the Cell·Rong ShaoDon C Rockey
Feb 25, 2009·Expert Opinion on Investigational Drugs·Kelly R Pitts
Feb 22, 2014·International Journal of Molecular Sciences·Richard SchäferLusine Danielyan
May 16, 2002·Journal of Cellular Physiology·Rong Shao, Don C Rockey
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C Rockey
Oct 8, 2020·Environmental Science and Pollution Research International·Ashwani Kumar SharmaAmrit Pal Singh
Nov 21, 1998·Journal of Hepatology·A GabrielC R Gandhi
Feb 19, 1999·Lancet·J GoulisA K Burroughs
Aug 23, 2001·Pharmacology & Therapeutics·P A CahillJ V Sitzmann
Oct 7, 2004·Journal of Hepatology·Chinnasamy ThirunavukkarasuChandrashekhar R Gandhi
Dec 20, 2005·Brain Research·Aline S C FabricioGlória E P Souza
Nov 18, 2006·The International Journal of Biochemistry & Cell Biology·Ajay K MudduDerek A Mann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.