Abstract
No gold standard has been established as a primary endpoint in trials of initial treatment of chronic graft-versus-host disease (GVHD), and evidence showing the association of any proposed primary endpoint with clinical benefit has not been conclusively demonstrated. To address this gap, we analyzed outcomes in a cohort of 328 patients enrolled in a prospective, multicenter, observational study within 3 months after diagnosis of chronic GVHD. Complete and partial response, stable disease, and progressive disease were defined according to the 2014 National Institutes of Health Consensus Development Conference on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease. Success was defined as complete or partial response with no secondary systemic treatment or recurrent malignancy at 1 year after enrollment. Success was observed in fewer than 20% of the patients. The burden of disease manifestations at 1 year was lower for patients in this category than for those with stable or progressive disease. Systemic treatment ended earlier, and subsequent mortality was lower among patients with complete or partial response than among those with stable or progressive disease and those who had received secondary systemic treatment....Continue Reading
References
Feb 2, 1997·Bone Marrow Transplantation·R P McQuellonD D Hurd
Feb 27, 2001·Blood·G B Vogelsang
Sep 18, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie k LeeJoseph H Antin
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
May 28, 2009·Blood·Afonso C VigoritoUNKNOWN National Institutes of Health
Jan 26, 2011·Blood·Mary E D FlowersPaul J Martin
Jun 15, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·UNKNOWN Chronic GVHD Consortium
Jan 17, 2013·Blood·Yoshihiro InamotoPaul J Martin
Apr 16, 2013·Bone Marrow Transplantation·L F NewellC Delaney
May 31, 2014·Blood·Yoshihiro InamotoPaul J Martin
Jun 11, 2014·Blood·Gérard Socié, Jerome Ritz
Nov 16, 2014·Blood·Mary E D Flowers, Paul J Martin
Feb 26, 2015·Haematologica·Jeanne PalmerStephanie J Lee
Mar 23, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeSteven Pavletic
May 20, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paul J MartinCorey S Cutler
Nov 4, 2015·Blood·Jeanne PalmerStephanie J Lee
May 24, 2016·Bone Marrow Transplantation·S Z AkiM E D Flowers
Nov 9, 2016·Blood·Stephanie J Lee
Citations
Nov 25, 2017·Blood·Hildegard T Greinix
Sep 20, 2017·Blood·David MiklosSamantha Jaglowski
Jan 25, 2019·Blood·Stefanie SarantopoulosKeith M Sullivan
Oct 4, 2019·Nature Communications·Naoya UchidaJohn F Tisdale
Apr 3, 2019·Blood Advances·Roger BelizaireJohn Koreth
Feb 27, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bellinda L King-KallimanisPaul G Kluetz
May 10, 2018·Bone Marrow Transplantation·Marietta NygaardHenrik Sengeløv
Jul 25, 2019·Blood Advances·Madan JagasiaHildegard T Greinix
Aug 4, 2019·Annals of Hematology·Sebastian KlobuchDaniel Wolff
Feb 23, 2020·Frontiers in Immunology·Matthew MankariousArun Alfred
Feb 23, 2020·Annals of Hematology·Anna-Sophia KattnerDaniel Wolff
Apr 26, 2020·Bone Marrow Transplantation·A OlivieriF Bonifazi
Oct 5, 2018·JCI Insight·Jonathan C PoeStefanie Sarantopoulos
Aug 24, 2018·Molecular Medicine·Andrea ZivotLionel Blanc
Jul 22, 2017·Blood·Nicolaus Kröger
Mar 19, 2020·Annals of Hematology·Roberto CrocchioloMauricette Michallet
Feb 20, 2020·Stem Cell Research & Therapy·Cynthia Morata-TarifaRosario Sanchez-Pernaute
Jan 28, 2021·JAMA Network Open·Hengwei WuYanmin Zhao
Jan 29, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ran ReshefJohn E Levine
Sep 12, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Badri ModiRyotaro Nakamura
Apr 12, 2021·Transplantation and Cellular Therapy·Carrie L KitkoCorey Cutler
Apr 21, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Madan JagasiaStephanie J Lee
May 6, 2021·Bone Marrow Transplantation·Panayotis KaloyannidisHani Al Hashmi
Jun 21, 2021·Transplantation and Cellular Therapy·Zachariah DeFilippHildegard T Greinix
Jul 15, 2021·The New England Journal of Medicine·Robert ZeiserUNKNOWN REACH3 Investigators