An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast

PLoS Genetics
Witawas HandeeMin-Hao Kuo

Abstract

Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer chronological lifespan was observed. Increased TAG abundance through the deletion of TAG lipases prolonged chronological lifespan of laboratory strains, while diminishing TAG biosynthesis shortened lifespan without apparently affecting vegetative growth. TAG-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. Because both lifespan regulation and TAG metabolism are conserved, this cellular pro-longevity function of TAG may extend to other organisms.

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Citations

May 28, 2016·Current Genetics·Xiaobo LiMin-Hao Kuo
Jan 28, 2017·Molecular BioSystems·Darleny Y LizardoG Ekin Atilla-Gokcumen
Jan 10, 2017·Biotechnology for Biofuels·Erin L BredewegScott E Baker
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Oct 20, 2020·ELife·Mitsuru ShinoharaGuojun Bu
Oct 9, 2020·Ageing Research Reviews·Andrey A ParkhitkoNorbert Perrimon
Apr 24, 2021·Developmental Cell·Ayse Sena MutluMeng C Wang
Dec 7, 2021·Frontiers in Cell and Developmental Biology·Melanie KovacsMark Rinnerthaler

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Methods Mentioned

BETA
environmental stress
Thin-layer
transgenic
PCR
fluorescence microscopy

Software Mentioned

KMsurv
R

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