An enhanced home cage modulates hypothalamic CRH-ir labeling in juvenile rats, with and without sub-threshold febrile convulsions

Developmental Psychobiology
Austin C KorganTara S Perrot

Abstract

Pre and postnatal environments can have a profound impact on offspring development. This is especially true when considering the origin of neurological diseases, including epilepsy, a relatively common and chronic neurological condition, affecting 1-2% of the population. Previously, we have used maternal stress and an enhanced home cage (EHC) in an effort to identify potential factors in the early environment that may increase the risk for experiencing seizures. First, pregnant Long-Evans rats were exposed to a predator stress (PS). Then, at birth, litters were divided into standard cage (SC) and EHC groups until postnatal Day 14 (PD14) when a model of febrile convulsions was used to determine convulsion susceptibility of the various groups. Twenty-four hours later, pup brains were processed for immunohistochemical detection of corticotrophic releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus. Analysis of CRH immunoreactive (-ir) patterns revealed a buffering of CRH-ir in EHC reared offspring. Further, experiencing convulsions led to decreased CRH-ir. Our results support the concept that postnatal environmental influences affect neonatal programming and neurodevelopment of processes that could underlie s...Continue Reading

References

Jul 16, 1991·Brain Research. Developmental Brain Research·T Z Baram, L Schultz
Jul 1, 1988·Epilepsia·F MarrosuG L Gessa
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 1, 1986·Journal of Applied Physiology·D E Spiers, E R Adair
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Feb 1, 1995·Epilepsy Research·G T GoldenP F Reyes
Oct 1, 1994·Molecular and Cellular Neurosciences·S J YiT Z Baram
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney
Oct 29, 2004·Epilepsia·James G HeidaQuentin J Pittman
Jan 18, 2005·Epilepsy & Behavior : E&B·Karl O NakkenLinda A Corey
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul M PlotskyMichael J Meaney
Feb 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ian C G WeaverMoshe Szyf
Sep 5, 2006·Epilepsy & Behavior : E&B·A R MesquitaN Sousa
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Marta Weinstock
Jul 23, 2008·Current Opinion in Pharmacology·Frances A Champagne, James P Curley
May 21, 2010·Epilepsy & Behavior : E&B·Mahzad Mehrzad Sadaghiani, Ehsan Saboory
Nov 27, 2010·Journal of Neuroendocrinology·S SalomonM Weinstock
May 7, 2011·Developmental Psychobiology·Ramin AhmadzadehAli Asghar Pilehvarian
Apr 25, 2012·Metabolic Brain Disease·Lihle QuluMusa V Mabandla
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordan MarroccoSara Morley-Fletcher
Mar 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katelin P PattersonShlomo Shinnar

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.