PMID: 9179062Jun 1, 1997Paper

An enhanced prognostic system for clinically localized carcinoma of the prostate

Cancer
T M PisanskyD G Bostwick

Abstract

This investigation was conducted to develop an enhanced prognostic system based on readily available and independently predictive tumor-related factors for patients with clinically localized prostate carcinoma. The outcome of 500 patients treated solely with irradiation for clinical TNM classifications T1-4, NO or NX, MO prostate carcinoma was used to identify factors independently associated with disease relapse. Logistic regression constructed a risk score equation, and optimized cutoff points to characterize patient groups with low, intermediate, or high risks for relapse were established with receiver operating characteristic curve analysis. Clinical tumor stage (P < 0.00001), Gleason score (P = 0.0002), and pretherapy serum prostate specific antigen (P < 0.00001) were independently associated with clinical or biochemical relapse. These factors were included in a risk score equation that defined patient groups with a distinctly different outcome. For the low, intermediate, and high risk groups, the relapse-free probabilities at 5 years after irradiation were 92%, 67%, and 24%, respectively (P < 0.00001). Readily available, pretherapy disease-related characteristics formed the basis of an enhanced prognostic system for patie...Continue Reading

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Citations

Dec 17, 2009·Future Oncology·Shahrokh F ShariatPeter T Scardino
Nov 24, 2011·Advances in Urology·Ariel E MarciscanoNicholas Sanfilippo
Jan 1, 1989·International Reviews of Immunology·K E Hellström, I Hellström
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Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
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Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Geoffrey S HigginsGrahame C W Howard
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