An enigmatic disease: childhood Langerhans cell histiocytosis in 2005

International Journal of Dermatology
Süreyya Savaşan

Abstract

Histiocytic proliferative diseases, although rare, constitute a challenge for pediatric pathologists and hematologists/oncologists because of difficulties in the identification of subtypes and the lack of established standard therapies, resulting in treatment failures, recurrences, or complications. Amongst the different types of such disorders, Langerhans cell histiocytosis (LCH) has been enigmatic to all involved, secondary to a long list of unresolved issues in pathogenesis and treatment. The fundamental dispute over its neoplastic vs. reactive nature remains unsettled. Unique features of LCH, including clonality, cases with spontaneous regression, frequent recurrences, and target tissue/organ tropism, have attracted significant interest. This article reviews the current understanding of LCH in the light of discoveries over the last few decades.

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Citations

Sep 3, 2010·Ear and Hearing·Erin M Picou, Todd A Ricketts
Apr 24, 2008·Pediatric Dermatology·Javier MataixCristina Moscardó-Guilleme
Jun 26, 2008·Pediatric Dermatology·Elizabeth K Satter, Whitney A High
Mar 21, 2008·Journal of Neurosurgery. Pediatrics·Laurence DavidsonMark D Krieger
May 16, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sabine SchmidtFrancois Gudinchet
Mar 14, 2008·Pediatric Annals·Vani SelvanOsvaldo Regueira
Nov 15, 2008·International Journal of Dermatology·Klara MosterdMaurice A M van Steensel
Oct 24, 2009·Anais Brasileiros De Dermatologia·Leonardo Mello FerreiraIsabella Redighieri

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