An entomopoxvirus homologue of the vaccinia virus D13L-encoded 'rifampicin resistance' protein

The Journal of General Virology
R J OsborneD Dall

Abstract

The Heliothis armigera entomopoxvirus (HaEPV) genome encodes a predicted 68 kDa polypeptide related to the 'rifampicin resistance' protein of vaccinia virus (with 30 % identity), and an homologous swinepox virus protein (27% identity). We were unable to isolate an HaEPV genotypic variant encoding a predicted C-terminal truncated form of the protein, suggesting that the C terminus of the molecule may be essential to protein function, and, in turn, that this function may be essential to viral replication. HaEPV replication was substantially reduced in host cells exposed to rifampicin, but the observed cytotoxic properties of the drug made it impossible to determine the specific cause of that inhibition. We suggest that possession of a gene encoding a member of this polypeptide family might represent a defining molecular characteristic of the Poxviridae.

Citations

Feb 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D DallD O'Reilly
Jul 3, 2015·Journal of Virology·Mona C GjessingOle Bendik Dale
Dec 16, 1998·Journal of Virology·C L AfonsoD L Rock

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