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An Enumerative Combinatorics Model for Fragmentation Patterns in RNA Sequencing Provides Insights into Nonuniformity of the Expected Fragment Starting-Point and Coverage Profile

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

Mar 1, 2017

Celine Prakash, Arndt Von Haeseler

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Abstract

RNA sequencing (RNA-seq) has emerged as the method of choice for measuring the expression of RNAs in a given cell population. In most RNA-seq technologies, sequencing the full length of RNA molecules requires fragmentation into smaller pieces. Unfortunately, the issue of nonuniform sequ...read more

Mentioned in this Paper

cDNA Probes
Genome
RNA
Two-Parameter Models
Gene Dosage
Fragmentation Procedure
Poly(A) Tail
Nested Polymerase Chain Reaction
Abnormal Fragmented Structure
Patterns
4
17
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  • An Enumerative Combinatorics Model for Fragmentation Patterns in RNA Sequencing Provides Insights into Nonuniformity of the Expected Fragment Starting-Point and Coverage Profile

    Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

    Mar 1, 2017

    Celine Prakash, Arndt Von Haeseler

    PMID: 27661099

    DOI: 10.1089/cmb.2016.0096

    Abstract

    RNA sequencing (RNA-seq) has emerged as the method of choice for measuring the expression of RNAs in a given cell population. In most RNA-seq technologies, sequencing the full length of RNA molecules requires fragmentation into smaller pieces. Unfortunately, the issue of nonuniform sequ...read more

    Mentioned in this Paper

    cDNA Probes
    Genome
    RNA
    Two-Parameter Models
    Gene Dosage
    4
    17

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