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An Enumerative Combinatorics Model for Fragmentation Patterns in RNA Sequencing Provides Insights into Nonuniformity of the Expected Fragment Starting-Point and Coverage Profile

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

Sep 24, 2016

Celine Prakash, Arndt Von Haeseler

Abstract

RNA sequencing (RNA-seq) has emerged as the method of choice for measuring the expression of RNAs in a given cell population. In most RNA-seq technologies, sequencing the full length of RNA molecules requires fragmentation into smaller pieces. Unfortunately, the issue of nonuniform sequ...read more

Mentioned in this Paper

Patterns
Gene Dosage
Abnormal Fragmented Structure
Genome
Sequence Determinations, RNA
Expected
Technology, Health Care
Nucleic Acid Sequencing
Genomics
Sequencing
4
17
Paper Details
References
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  • Citations
123
  • References24
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An Enumerative Combinatorics Model for Fragmentation Patterns in RNA Sequencing Provides Insights into Nonuniformity of the Expected Fragment Starting-Point and Coverage Profile

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

Sep 24, 2016

Celine Prakash, Arndt Von Haeseler

PMID: 27661099

DOI: 10.1089/cmb.2016.0096

Abstract

RNA sequencing (RNA-seq) has emerged as the method of choice for measuring the expression of RNAs in a given cell population. In most RNA-seq technologies, sequencing the full length of RNA molecules requires fragmentation into smaller pieces. Unfortunately, the issue of nonuniform sequ...read more

Mentioned in this Paper

Patterns
Gene Dosage
Abnormal Fragmented Structure
Genome
Sequence Determinations, RNA
Expected
Technology, Health Care
Nucleic Acid Sequencing
Genomics
Sequencing
4
17

Similar Papers Found In These Feeds

Drug & Digital Interventions

This feed describes how digital interventions, which are digital and mobile technologies used to support health system needs, can complement and improve pharmacotherapy in disease management. Discover the latest research on drug and digtial intervention here,

Related Papers

Genome Biology

Improving RNA-Seq expression estimates by correcting for fragment bias

Genome BiologyMarch 18, 2011
Adam RobertsLior Pachter
Biostatistics

Modeling RNA degradation for RNA-Seq with applications

BiostatisticsFebruary 23, 2012
Lin WanFengzhu Sun
Paper Details
References
  • References24
  • Citations
123
  • References24
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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