An Environmental influences on Child Health Outcomes viewpoint of data analysis centers for collaborative study designs

Current Opinion in Pediatrics
Lisa P JacobsonCorette B Parker

Abstract

A highly complex collaborative study design that pools and extends existing studies, such as the Environmental influences on Child Health Outcomes (ECHO) Program, requires a Data Analysis Center (DAC) with resources and expertise to create a secure environment for housing and analyzing the shared data, harmonize and structure the shared data for different purposes, and apply appropriate and innovative designs and analytic methods. The DAC, in partnership with cohort investigators, must ensure that results from ECHO-wide cohort analyses are appropriately interpreted and reproducible. Understanding the cohorts contributing to ECHO is critical for developing a collaborative environment and the methods to best analyze the data without bias. We further describe the development of the ECHO-wide cohort Metadata Catalog, the architecture of the ECHO-wide cohort data platform, and analytical approaches to facilitate early productivity. The ECHO DAC has established a secure environment for the transfer and storage of ECHO cohort data and information, and initiated processes to promote productive collaborations. Understanding the ECHO DAC responsibilities and assets will help to overcome communication and trust challenges encountered in t...Continue Reading

References

Jan 11, 2007·International Journal of Epidemiology·Stephen J GangeRichard D Moore
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Susan L FurthBradley A Warady
Jun 22, 2010·American Journal of Epidemiology·Kathy J Helzlsouer, UNKNOWN VDPP Steering Committee
Dec 18, 2012·International Journal of Epidemiology·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Feb 5, 2015·American Journal of Obstetrics and Gynecology·David M HaasUNKNOWN NuMoM2b study
May 12, 2016·The New England Journal of Medicine·N L'ntshotsholé JumbeSteven Kern

❮ Previous
Next ❯

Citations

May 27, 2021·Pediatric Research·Megan E RomanoUNKNOWN program collaborators for Environmental influences on Child Health Outcomes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.