An enzymatic system for removing heparin in extracorporeal therapy

Science
R LangerM Klein

Abstract

The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.

Citations

Dec 20, 2002·Angewandte Chemie·Ishan Capila, Robert J Linhardt
Dec 20, 1989·Biotechnology and Bioengineering·A R ComfortR Langer
Aug 5, 1992·Biotechnology and Bioengineering·X MaS W Kim
Mar 1, 1993·Journal of Biomedical Materials Research·X MaS W Kim
Feb 1, 1981·Applied and Environmental Microbiology·P M GalliherRobert J Linhardt
Jan 1, 1993·Annals of Biomedical Engineering·L E FreedR Langer
Jan 1, 1993·Annals of Biomedical Engineering·L E FreedR Langer
Sep 1, 1987·Applied Biochemistry and Biotechnology·V C YangR Langer
Sep 1, 1987·Applied Biochemistry and Biotechnology·H BernsteinR Langer
Feb 1, 1984·Applied Biochemistry and Biotechnology·Robert J LinhardtR Langer
Aug 1, 1991·Applied Biochemistry and Biotechnology·J J ZimmermannC L Cooney
Nov 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P J Stow, F A Burrows
Jan 1, 1985·The International Journal of Biochemistry·Robert J LinhardtD W Persinger
Mar 1, 1993·The International Journal of Biochemistry·K GuRobert J Linhardt
Jun 5, 2002·Biochimica Et Biophysica Acta·Ishan CapilaRobert J Linhardt
Jun 12, 2013·Nature Biotechnology·R Langer
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LabequeR Langer
Dec 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Chin Toh, Joel Voldman
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·G A AmeerR Langer
Sep 1, 1990·Journal of Cardiac Surgery·J R Utley
Oct 4, 2006·Current Opinion in Anaesthesiology·M Schetz
Jul 30, 2005·Anesthesiology·Mark Stafford-SmithMembers of the Global Perioperative Research Organization
Jan 1, 1995·Critical Reviews in Biochemistry and Molecular Biology·S ErnstR Sasisekharan
Jan 1, 1987·Biomaterials, Artificial Cells, and Artificial Organs·Robert J Linhardt, R Langer
Apr 2, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Gözde Baydemir, Adil Denizli
Jul 5, 2006·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·M Sunil VargheseD M Rubin
Oct 1, 1987·Kidney International·H BernsteinR Langer
Apr 26, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Saravanababu MurugesanRobert J Linhardt
Mar 1, 1991·Journal of Pediatric Surgery·G C WhittleseyM D Klein
Nov 15, 1990·Thrombosis Research·L H BöhmerL Visser
Aug 5, 1987·Biotechnology and Bioengineering·H BernsteinR Langer
Jan 1, 1988·Annals of the New York Academy of Sciences·V C YangR Langer
Aug 5, 1988·Biotechnology and Bioengineering·A R ComfortR Langer
Dec 2, 1999·Heart & Lung : the Journal of Critical Care·R Porsche, Z R Brenner
Dec 14, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jyothi MaddineniJawed Fareed
Feb 1, 1984·Analytical Biochemistry·A C GrantR Langer
Oct 4, 2017·Glycobiology·Indu BhushanUmesh R Desai
Feb 9, 1996·The Journal of Biological Chemistry·R SasisekharanR Langer
Aug 11, 2018·Applied Microbiology and Biotechnology·Svenja Nicolin BoltenThomas Scheper
Aug 5, 1987·Biotechnology and Bioengineering·H BernsteinR Langer
Aug 17, 2020·Journal of Chromatography. a·Svenja Nicolin BoltenThomas Scheper
Jun 13, 2003·Journal of Medicinal Chemistry·Robert J Linhardt
Feb 15, 1997·Archives of Biochemistry and Biophysics·C F MoffatF B Williamson

Related Concepts

Extracorporeal Circulation
Flavobacterium genus
Hemodialysis
Hemorrhage
Liquaemin
Polysaccharide-Lyases
Heparin Lyase

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
H Bernstein, R Langer
Biotechnology and Bioengineering
H BernsteinR Langer
Proceedings of the National Academy of Sciences of the United States of America
R SasisekharanR Langer
© 2021 Meta ULC. All rights reserved