An enzymatic system for removing heparin in extracorporeal therapy

R LangerM Klein


The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.


Dec 20, 2002·Angewandte Chemie·Ishan Capila, Robert J Linhardt
Dec 20, 1989·Biotechnology and Bioengineering·A R ComfortR Langer
Aug 5, 1992·Biotechnology and Bioengineering·X MaS W Kim
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Feb 1, 1981·Applied and Environmental Microbiology·P M GalliherRobert J Linhardt
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