An epidemiological analysis of osteoporotic characteristics in patients affected with rheumatoid arthritis in Kazakhstan

Archives of Osteoporosis
Gulzhan GabdulinaGregory Livshits

Abstract

We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. Four hundred six RA patients (90.6% females) with 397 controls-unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN), and US_T-scores. In the RA affected female population, ~ 80% suffered from osteopenia or osteoporosis. All OP-RP were negatively correlated with age and female's sex, as expected, and thus accordingly adjusted, resulting in consistent, significantly [p = 0.016 (CI), p < 0.0001 (both BMDSPN and US_T-scores)] lower OP-RP estimates in affected females. Using multiple regression analysis for OP-RP manifestations, only age and disease duration appeared consistently associated with all three studied phenotypes, while menopause status or years following the onset of menopause were also significant for BMDSPN and US_T-scores. However, when disease duration was examined, we found that it was significantly dependent on morning st...Continue Reading

References

Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N E LaneM C Nevitt
May 20, 1998·Arthritis and Rheumatism·C M WeyandJ J Goronzy
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Jun 9, 2001·Rheumatic Diseases Clinics of North America·S E Gabriel
Oct 2, 2001·Scandinavian Journal of Rheumatology·C KellerUNKNOWN BARFOT study group
Jul 12, 2002·Arthritis Research·Alan J Silman, Jacqueline E Pearson
Aug 7, 2007·Postgraduate Medical Journal·Glen M Blake, Ignac Fogelman
Sep 12, 2008·Best Practice & Research. Clinical Rheumatology·Arvind Chopra, Ahmed Abdel-Nasser
Aug 18, 2009·European Journal of Radiology·Judith E Adams
Oct 27, 2009·Annals of the Rheumatic Diseases·Elena MyasoedovaSherine E Gabriel
Dec 8, 2009·Rheumatic Diseases Clinics of North America·Theodore Pincus, Tuulikki Sokka
Nov 8, 2011·Rheumatology International·Shengqian XuJianhua Xu
Nov 16, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Eman A HafezMona Ahmed Ismail
Oct 15, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roland KocijanGeorg Schett
Feb 26, 2016·BMC Musculoskeletal Disorders·Joo-Hyun LeeSang-Cheol Bae
May 23, 2017·BioMed Research International·Hui PiYoulian Wang
Jul 29, 2017·Diabetes & Metabolic Syndrome·Rajesh RajputHarpreet Singh
Mar 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S JinX Zeng
May 15, 2018·The Open Rheumatology Journal·Shaymaa Abdalwahed AbdulameerSyed Azhar Syed Sulaiman

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Citations

Dec 16, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Melody KasherGregory Livshits

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