Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. Using an innovative two-step process, we develop a new epigenetic biomarker of aging, DNAm PhenoAge, that strongly outperforms previous measures in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer's disease. While this biomarker was developed using data from whole blood, it correlates strongly with age in every tissue and cell tested. Based on an in-depth transcriptional analysis in sorted cells, we find that increased epigenetic, relative to chronological age, is associated with increased activation of pro-inflammatory and interferon pathways, and decreased activation of transcriptional/translational machinery, DNA damage response, and mitochondrial signatures. Overall, this single epigenetic ...Continue Reading
Associated Clinical Trials
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity
Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition
Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort
Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?
DNA methylation-based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies
A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Testing Life Course Models Whereby Juvenile and Adult Adversity Combine to Influence Speed of Biological Aging
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology
Individual DNA Methylation Profile is Correlated with Age and can be Targeted to Modulate Healthy Aging and Longevity
Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals
Integrating DNA methylation measures to improve clinical risk assessment: are we there yet? The case of BRCA1 methylation marks to improve clinical risk assessment of breast cancer.
The Effect of Tobacco Smoking Differs across Indices of DNA Methylation-Based Aging in an African American Sample: DNA Methylation-Based Indices of Smoking Capture These Effects.
Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics.
Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males.
Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.
Blood-derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs
Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo
Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood.
Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.
Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts
Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging
Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients
Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study
Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue.
Biological and Functional Biomarkers of Aging: Definition, Characteristics, and How They Can Impact Everyday Cancer Treatment.
Epigenetic Discrimination: Emerging Applications of Epigenetics Pointing to the Limitations of Policies Against Genetic Discrimination
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study
Education and Lifestyle Factors Are Associated with DNA Methylation Clocks in Older African Americans
DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921
Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated
Comparing biological age estimates using domain-specific measures from the Canadian Longitudinal Study on Aging
Postmortem age estimation via DNA methylation analysis in buccal swabs from corpses in different stages of decomposition-a "proof of principle" study
Childhood intelligence attenuates the association between biological ageing and health outcomes in later life
Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity
Lifetime Ultraviolet Radiation Exposure and DNA Methylation in Blood Leukocytes: The Norwegian Women and Cancer Study.
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up.
A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging
A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation
Determination of the phenotypic age in residents of Mexico City: effect of accelerated ageing on lung function and structure
A Direct Comparison of the Relationship of Epigenetic Aging and Epigenetic Substance Consumption Markers to Mortality in the Framingham Heart Study
A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age
Mini Nutritional Assessment Scores Indicate Higher Risk for Prospective Mortality and Contrasting Correlation With Age-Related Epigenetic Biomarkers
Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight.
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration.
Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients.
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
Environmentally Induced Epigenetic Plasticity in Development: Epigenetic Toxicity and Epigenetic Adaptation
Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.
Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity
The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients
DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors
One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project.
Epigenetic clocks may come out of rhythm-implications for the estimation of chronological age in forensic casework.
Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia
DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure
The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden.
Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model.
The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations
Anti-tumor necrosis factor drug responses and skin-blood DNA methylation age: Relationships in moderate-to-severe psoriasis.
Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.
Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer.
Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study
Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential
DNA methylation ageing clocks and pancreatic cancer risk: pooled analysis of three prospective nested case-control studies.
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms.
GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.
The effects of social adversity, discrimination, and health risk behaviors on the accelerated aging of African Americans: Further support for the weathering hypothesis.
DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4.
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.
Deep learning encodes robust discriminative neuroimaging representations to outperform standard machine learning.
Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis.
A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission.
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.
Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study.
Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array.
The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging
The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor
Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment.
A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.
Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects.
Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.
DNA methylation and cancer incidence: lymphatic-hematopoietic versus solid cancers in the Strong Heart Study.
The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.
Invited Commentary: Epigenetic Clocks and Obesity-Towards the Next Frontier Using Integrative Approaches and Early-Life Models.
Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age Acceleration.
Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans.
How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia.
Epigenetic age acceleration changes 2 years after antiretroviral therapy initiation in adults with HIV: a substudy of the NEAT001/ANRS143 randomised trial.
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones.
Adopting a "Compound" Exposome Approach in Environmental Aging Biomarker Research: A Call to Action for Advancing Racial Health Equity.
Deep longitudinal phenotyping of wearable sensor data reveals independent markers of longevity, stress, and resilience.
An aging and p53 related marker: HOXA5 promoter methylation negatively correlates with mRNA and protein expression in old age.
Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
DNA methylation in the adipose tissue and whole blood of Agent Orange-exposed Operation Ranch Hand veterans: a pilot study.
Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study.
An Exploratory Study of Epigenetic Age in Preeclamptic and Normotensive Pregnancy Reveals Differences by Self-Reported Race but Not Pregnancy Outcome.
Adaptive metabolic and inflammatory responses identified using accelerated aging metrics are linked to adverse outcomes in severe SARS-CoV-2 infection.
DNA methylation patterns within whole blood of adolescents born from assisted reproductive technology are not different from adolescents born from natural conception.
DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic HBV or HCV, with or without HIV Co-Infection
Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study.
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration.
Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging.
Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning.
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study.
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer.
Cancer Epigenetics & Metabolism (Keystone)
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.
Aging Genetics (Keystone)
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
Cell Aging (Keystone)
This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
Cancer Epigenetics and Senescence (Keystone)
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.
Genetics & Epigenetics of Aging
Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.
Alzheimer's Disease: Transcription
Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.