An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley.

International Journal of Hygiene and Environmental Health
Melissa A FurlongBeate Ritz

Abstract

Pyrethroid pesticide use is increasing worldwide, although the full extent of associated health effects is unknown. An epigenome-wide association study (EWAS) with exploratory pathway analysis may help identify potential pyrethroid-related health effects. We performed an exploratory EWAS of chronic ambient pyrethroid exposure using control participants' blood in the Parkinson's Environment and Genes Study in the Central Valley of California (N = 237). We estimated associations of living and working near agricultural pyrethroid pesticide applications in the past 5 years (binary) with site-specific differential methylation, and used a false discovery rate (FDR) cut off of 0.05 for significance. We controlled for age, sex, education, cell count, and an ancestral marker for Hispanic ethnicity. We normalized methylation values for Type I/II probe bias using Beta-Mixture Quantile (BMIQ) normalization, filtered out cross-reactive probes, and evaluated for remaining bias with Surrogate Variable Analysis (SVA). We also evaluated the effects of controlling for cell count and normalizing for Type I/II probe bias by comparing changes in effect estimates and p-values for the top hits across BMIQ and GenomeStudio normalization methods, and c...Continue Reading

Citations

Apr 30, 2021·Chemical Research in Toxicology·Qi YanBeate R Ritz
Jul 1, 2021·Ecology and Evolution·Sabrina M McNewDale H Clayton
Sep 14, 2021·Environmental Health Perspectives·Thanh T HoangStephanie J London

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