An epithelial and spindle cell breast tumour of myoepithelial origin. An immunohistochemical and ultrastructural study.

Virchows Archiv. A, Pathological Anatomy and Histopathology
M H Enghardt, J H Hale

Abstract

An infiltrating epithelial and spindle cell neoplasm developed in the breast of a 63-year-old female. An excisional biopsy was performed. Recurrence with rapid growth due to cyst development eventually resulted in more radical surgery. Interim fine needle aspirations had established its partially cystic nature. The unique microscopic appearance prompted the application of immunohistochemistry and electron microscopy. The tumour cells were found to exhibit characteristics denoting squamous and myoepithelial differentiation. Histopathological features of malignancy were absent. Our findings demonstrate the differentiation potential of breast epithelium. They are in concordance with the results of previous studies which delineate the histochemical and ultrastructural features of myoepithelial and establish the relationship of these cells to squamous metaplasia.

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Citations

Oct 10, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·K ItoJ Amano
Apr 6, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K A BehranwalaG P H Gui
Jun 6, 2009·Pathology International·Hajime HikinoMasafumi Kurosumi
Jul 2, 2003·Journal of Clinical Pathology·M Pia-FoschiniS R Lakhani
Sep 1, 1995·Ultrastructural Pathology·J M HarbC M Vitali
Jun 2, 2006·The Journal of Pathology·J S Reis-FilhoF C Schmitt
Jul 18, 2006·Histopathology·J S Reis-FilhoF C Schmitt
Dec 26, 2003·Seminars in Diagnostic Pathology·Audrey K BennettMark R Wick
May 1, 1991·Cancer·R DekmezianB Mackay
Apr 29, 2016·Molecular and Clinical Oncology·Maria PapazianNikolaos Ziras

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