An essential requirement for osteoclasts in refined bone-like tissue reconstruction in vitro

Medical Hypotheses
Daqing Han, Qiqing Zhang

Abstract

One crucial but often disregarded problem in tissue-engineered bone is that osteoblasts in culture significantly differ in function and behavior from their counterparts in vivo. This difference is represented as an inability of cultured osteoblasts to form lamellar bone-like structures and deposit the characteristic mineral of native bone, as well as their loss of polarity of matrix secretion, marked by tissue growth bridging the pore interconnections of scaffolds. These abnormalities of in vitro bone formation are a major cause of the current failure to yield functional and mechanically competent bone. Recent studies with osteoclast deficient animal models have definitely revealed that the regulatory effect of osteoclasts is essential for normal bone formation. The abnormalities of bone formation present in osteoclast deficient animals are largely reflected in current tissue-engineered bone. Reasonably, the abnormalities of in vitro bone formation most likely result from the absence of osteoclasts in current bone formation strategies. Therefore, it is hypothesized that osteoclast introduction will provide a necessary solution to the critical problems in bone tissue engineering. The way of osteoclast introduction is the first c...Continue Reading

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Citations

Mar 10, 2012·Tissue Engineering. Part a·Ami R AminiSyam P Nukavarapu
Jun 19, 2012·Tissue Engineering. Part a·Hongli SunPaul H Krebsbach
Apr 5, 2011·The British Journal of Oral & Maxillofacial Surgery·Qing LiuYuxiang Ding
Aug 4, 2009·Biomaterials·Gemma L JonesSarah H Cartmell
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Rainer Detsch, Aldo R Boccaccini
Jan 7, 2010·Journal of Cellular and Molecular Medicine·R P PirracoR L Reis
Nov 21, 2009·Tissue Engineering. Part B, Reviews·Elizabeth A HornerXuebin B Yang

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