PMID: 11918558Mar 29, 2002Paper

An estimate of the current risk of transmitting blood-borne infections through blood transfusion in Italy

British Journal of Haematology
M E TostiA Mele

Abstract

We conducted a retrospective cohort study to estimate the incidence of major blood-borne agents among Italian blood donors and calculated the risk of infection among blood recipients using the 'incidence/window period model'. The study was conducted among 46 180 blood donors enrolled in six blood centres between 1994 and 1999. During follow-up, seven new infections were confirmed: three donors seroconverted for anti-human immunodeficiency virus (HIV); two for anti-hepatitis C virus (HCV); and two showed hepatitis B surface antigen (HBsAg) reactivity; no cases of syphilis were observed. The incidence rates per 100 000 person/years were: 4.06 (95% CI: 0.82-11.85) for HIV; 2.41 (95% CI: 0.29-8.70) for HCV; and 2.70 (95% CI: 0.32-9.77) for HBsAg; the incidence for total hepatitis B virus (HBV) infection was 9.77 per 100 000 person/years (95% CI: 1.16-35.36). The estimated risk of an infectious blood unit not being detected was: 2.45 (95% CI: 0.13-12.33) per 1 million units for HIV; 4.35 (95% CI: 0.30-22.39) for HCV; and 15.78 (95% CI: 1.16-84.23) for HBV. Overall, an estimated 22.58 per 1 million units are infected. In Italy, the risk of transfusion-transmitted infections is low and is similar to that in other western countries. Th...Continue Reading

References

Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·A MannsW A Blattner
Jan 1, 1988·Vox Sanguinis·H H Gunson, V I Rawlinson
Dec 28, 1995·The New England Journal of Medicine·E M LackritzL R Petersen
Sep 30, 1995·BMJ : British Medical Journal·A MeleF Novaco
May 5, 1993·JAMA : the Journal of the American Medical Association·J McCullough
Jun 27, 1996·The New England Journal of Medicine·G B SchreiberJ J Korelitz
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D PratiG Sirchia
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V GuadagninoM Piazza

❮ Previous
Next ❯

Citations

Sep 2, 2003·Transplantation Proceedings·P AndreoneM Bernardi
Jan 28, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D Prati
Feb 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alfonso MeleUNKNOWN National Surveillance System for Acute Viral Hepatitis (SEIEVA) Collaborating Group
Sep 9, 2008·The Journal of Antimicrobial Chemotherapy·Johannes WiegandHeiner Wedemeyer
Jan 20, 2006·Transplantation·Tullia M De FeoMario Scalamogna
Jan 18, 2005·Clinical Microbiology Reviews·Gabriel A Schmunis, Jose R Cruz
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T SantantonioT Stroffolini
Feb 22, 2011·Enfermedades infecciosas y microbiología clínica·María Martínez-RebollarMontserrat Laguno
Jul 10, 2009·The Journal of Infection·Stefano DettoriMaria Rapicetta
Jul 21, 2009·Journal of Hepatology·Daniel Candotti, Jean-Pierre Allain
Sep 9, 2016·Asian Journal of Transfusion Science·Leila Kasraian, Mohammad Hossein Karimi
Aug 19, 2008·Journal of Hepatology·Teresa SantantonioJ Tilman Gerlach
Oct 31, 2006·Memórias do Instituto Oswaldo Cruz·Ana F B AndradeCibele R Bonvicino
Mar 29, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Albert K MingaUNKNOWN ANRS 1220 PRIMO-CI Study Group
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Markus CornbergStefan Zeuzem
Aug 14, 2012·Transfusion·Cesar de Almeida-NetoUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component
Jul 13, 2006·International Journal of Immunopathology and Pharmacology·M MartinettiA Maccabruni
Jan 31, 2014·Journal of Clinical Laboratory Analysis·Linda SommeseClaudio Napoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.