PMID: 7083775Aug 1, 1982Paper

An estimate of the endogenous secretion rate of calcitonin in man

Clinical Science
J A KanisR G Russell

Abstract

1. The metabolic clearance rate (MCR) of human calcitonin was measured in 12 normal subjects and four patients with Paget's disease by the infusion of synthetic human calcitonin (15-40 microgram/h for 2-24 h), and in 10 additional patients with Paget's disease from the disappearance rate of immunoreactive calcitonin from plasma after the intravenous injection of large doses of synthetic human calcitonin (0.5-1.0 mg). 2. The estimated MCR during the infusion studies (range 531-1224 litres/day) was similar to that calculated from the disappearance of large doses of synthetic human calcitonin injected intravenously in patients with Paget's disease (mean = 1035 litres/day; range = 593-1408 litres/day). 3. An eightfold range in the basal values of plasma immunoreactive calcitonin, in spite of the presence of a relatively constant MCR, suggests that the variation in basal plasma calcitonin was due principally to variation in the endogenous secretion rate for calcitonin. 4. The results suggest that the endogenous secretion rate for calcitonin is low in normal subjects (mean 124 +/- SEM 24 microgram/day), and give a basis for selecting the doses of calcitonin which can be considered physiological.

Citations

Apr 1, 1985·Clinical Endocrinology·D F Guillard-CummingJ A Kanis
Aug 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D TiegsH Heath
Mar 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Y ReginsterP Franchimont
Jun 1, 1990·Journal of Endocrinological Investigation·M PedrazzoniM Passeri
May 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y ReginsterP Franchimont
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A KhanA G Porras
Sep 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Y ReginsterP Franchimont
Mar 31, 2015·Clinical Kidney Journal·Arnold J Felsenfeld, Barton S Levine

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