An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997-2010)

The British Journal of Dermatology
C-H HongC-H Lee

Abstract

Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 and TSC2, leading to mammalian target of rapamycin hyperactivation. Patients with TSC develop hamartomas in brain, lungs, liver and skin. Two epidemiological studies, performed in Minnesota, U.S.A., have estimated the incidence of TSC to be 0·28-0·56 per 100 000 person-years (PY), based on < 12 patients. Furthermore, whether common comorbidities are associated with this rare disease is not known. To estimate the incidence of TSC and investigate the associations of TSC with other comorbidities, including diabetes, peptic ulcers, stroke and myocardial infarction. We estimated the incidence and prevalence of TSC and its comorbidities from 1997 to 2010, based on the Catastrophic Illness Certificate disease database and a beneficiary cohort of 1 million people. The incidence of TSC in Taiwan is 0·153 per 100 000 PY. The number of patients identified with TSC in Taiwan doubled from 206 in 2006 to 471 in 2010. In 2010, the prevalence of TSC in Taiwan was estimated to be 1·58 in 100 000. We confirmed that female patients with TSC are more likely to develop renal tumours than male patients. Surprisingly, patients with TSC have a significantly decreased risk of developing pe...Continue Reading

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Citations

Jun 19, 2016·The British Journal of Dermatology·P J Morrison, D E Donnelly
Sep 27, 2018·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Angela PeronHope Northrup
Sep 14, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Stephen G Schwartz, J William Harbour
Oct 3, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Peter Trnka, Sean E Kennedy
Jan 23, 2020·Orphanet Journal of Rare Diseases·Johann Philipp ZöllnerAdam Strzelczyk
Apr 1, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Mariana Faucz Munhoz da CunhaFellype Carvalho Barreto
Nov 24, 2020·CNS Neuroscience & Therapeutics·Yifeng DingYi Wang
Jan 3, 2021·Pediatrics in Review·Arpita ChattopadhyayDiganta Saikia
Mar 12, 2021·Journal of Tropical Pediatrics·Yajie SuLong Li
Jun 29, 2021·Neurological Research and Practice·Johann Philipp ZöllnerAdam Strzelczyk

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