An Estrogen-Related Dietary Pattern and Postmenopausal Breast Cancer Risk in a Cohort of Women with a Family History of Breast Cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mark A GuinterSusan E Steck

Abstract

Background: The results of previous studies on diet and postmenopausal breast cancer risk have been inconclusive, but there is some evidence that dietary patterns developed to correlate with estrogen levels are associated with breast cancer. We aimed to examine the association of a previously developed estrogen-related dietary pattern (ERDP) with postmenopausal breast cancer in the Sister Study.Methods: The ERDP was calculated from food frequency questionnaire responses among Sister Study participants without a personal history of cancer and who contributed postmenopausal person-time at risk. Cox proportional hazards models were used to estimate HRs and 95% confidence intervals for the association between the ERDP and postmenopausal breast cancer.Results: With more than 261,959 person-years of follow-up and 1,968 incident cases, the ERDP was not associated with total, invasive, estrogen receptor (ER)-positive or ER-negative subtypes of breast cancer. Results were robust to various sensitivity analyses.Conclusions: The results do not support previous studies observing a positive association between a proestrogenic dietary pattern and postmenopausal breast cancer risk. Null results may be partially explained by high levels of oth...Continue Reading

References

Apr 18, 2009·Endocrinology·Margot P Cleary, Michael E Grossmann
Jan 6, 2012·Breast Cancer Research and Treatment·Teresa T FungMichelle D Holmes
Jan 11, 2012·Journal of the National Cancer Institute·Barbara J FuhrmanRegina G Ziegler
May 1, 2015·International Journal of Cancer. Journal International Du Cancer·Holly R HarrisAlicja Wolk
Jan 13, 2016·British Journal of Cancer·Anja RudolphMarjanka K Schmidt
Jan 27, 2018·Environmental Health Perspectives·Dale P SandlerUNKNOWN Sister Study Research Team
Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Mark A GuinterSusan E Steck

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Citations

Dec 19, 2019·Nature Reviews. Cancer·Susan E Steck, E Angela Murphy
Mar 6, 2019·The British Journal of Nutrition·Larissa Hansen MarcondesJessica C Kiefte-de Jong

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