PMID: 8588065Jul 1, 1995Paper

An ethologically based, stimulus and gender-sensitive nonhuman primate model for anxiety

Progress in Neuro-psychopharmacology & Biological Psychiatry
J D Newman, M J Farley

Abstract

1. Adult male and female squirrel monkeys were tested for behavioral responses to 5 min. social separation (alone in test room) followed by 30-sec. exposure to 2 humans wearing a leather capture glove. 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg. 3. Measured behaviors were number and type of vocalization and locomotor activity (duration in sec) in each of the two testing conditions. 4. A dose-response relationship for bark/yap vocalizations during the 30-sec trials was established, with 1.0 mg/kg being the most effective dose. 5. Males and females differed in the number of barks/yaps produced during 30-sec. trials at every drug dose. 6. The present testing paradigm provides the basis for efficiently determining the extent of gender differences in dose/response relationships for drugs of possible therapeutic value in the treatment of anxiety-related behavioral disorders.

References

Jan 1, 1991·Neuroscience and Biobehavioral Reviews·L J Crepeau, J D Newman
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·T R Insel, C R Harbaugh
Jan 1, 1986·Psychopharmacology·J R Glowa, J D Newman
Apr 1, 1986·The American Journal of Psychiatry·E M ReimanJ Perlmutter
Jun 1, 1987·Biological Psychiatry·T R Insel, J L Hill
May 1, 1993·Scientific American·N H Kalin

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Citations

Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·J Cilia, D C Piper
Feb 22, 2002·Neuroscience and Biobehavioral Reviews·Marilia Barros, Carlos Tomaz
Jan 15, 1997·Annals of the New York Academy of Sciences·C T Snowdon
Mar 14, 2008·Epilepsy & Behavior : E&B·João C BachiegaLuiz E Mello
May 6, 2009·Pharmacology, Biochemistry, and Behavior·Priscila CagniMarilia Barros

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