An evaluation of apomorphine action on doapminergic receptors

Experientia
P C DandiyaR S Gambhir

Abstract

The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evlauation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO hold trans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydrxonaphthalene) incorporates trans-transcoid conformation and primarily acts on post-synpatic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.

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Citations

Jul 1, 1983·The Journal of Pharmacy and Pharmacology·M G FeenstraA S Horn
Jul 1, 1980·The Journal of Pharmacy and Pharmacology·A S Horn, J R Rodgers
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