PMID: 6172353Jan 1, 1982Paper

An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S Sell, H L Leffert

Abstract

Analysis of liver from rats exposed to chemical hepatocarcinogens has led to a model that postulates sequential premalignant changes, culminating in hepatoma formation from neoplastic nodules. Several experimental protocols devised during the last quarter century have focused upon this lineage model. But proof that neoplastic nodules are the definitive premalignant lesions has not been achieved. Recent work, using alpha-fetoprotein as a marker for liver cell alterations induced by different carcinogen-feeding regimens, suggests that chemically induced hepatomas may also arise from nonnodular cell populations. Therefore, the extensive biochemical and biological studies of presumed "premalignant" cells may have utilized the wrong cells. Unequivocal identification of the cell population at risk for malignancy is needed to delineate mechanisms by which chemicals cause hepatocellular carcinoma.

References

Sep 15, 1977·International Journal of Cancer. Journal International Du Cancer·T A TchipyshevaG A Bannikov
Jan 1, 1978·Journal of the National Cancer Institute·S Sell, F F Becker
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·W D Kuhlmann
Jan 1, 1976·Frontiers of Gastrointestinal Research·S Goldfarb, H C Pitot
Jan 1, 1979·Methods in Enzymology·H L LeffertM Williams
Jul 1, 1976·Journal of the National Cancer Institute·G M WilliamsE Farber
Jan 1, 1975·Annual Review of Biochemistry·C Heidelberger
Sep 15, 1972·International Journal of Cancer. Journal International Du Cancer·T KitagawaH Sugano
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W H HabigW B Jakoby
Jan 1, 1980·Advances in Cancer Research·E Farber, R Cameron
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·A Y Lu, G T Miwa
Jan 1, 1980·Annals of the New York Academy of Sciences·K S Koch, H L Leffert
Jan 1, 1963·Advances in Cancer Research·E FARBER

❮ Previous
Next ❯

Citations

Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C C HsiaS S Thorgeirsson
Nov 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K S KochH L Leffert
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y SasakiT Kamada
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseD S Krause
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Li YinStewart Sell
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S Sell
May 6, 2006·Stem Cells·Maggie H Walkup, David A Gerber
Apr 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·N MarceauM Noel
Nov 1, 1991·Electrophoresis·P J WirthA D Olson
Jul 1, 1988·Japanese Journal of Cancer Research : Gann·H TakahashiR Masuda
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K Aterman
Aug 1, 1985·Archives of Toxicology·R Schulte-Hermann
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Sell
Jun 29, 2010·Veterinary and Comparative Oncology·B CogliatiM L Z Dagli
Feb 15, 1983·International Journal of Cancer. Journal International Du Cancer·G M LeddaB Lombardi
Oct 13, 2006·Current Opinion in Gastroenterology·R J Stockert, A W Wolkoff
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stewart Sell, Hyam L Leffert
Feb 1, 2008·Expert Opinion on Drug Discovery·Bruce C Baguley, Elaine S Marshall
Sep 1, 1996·Toxicologic Pathology·T E Bunton
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseD S Krause
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·P GalandK Alexandre
Mar 30, 2012·Science Signaling·Suchithra MenonBrendan D Manning
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RosenbergS Sell
Sep 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ian GuestStewart Sell
Dec 1, 1991·The American Journal of Physiology·M DarbouyY Laperche
Apr 6, 2001·The American Journal of Pathology·S PakuS S Thorgeirsson
Mar 6, 1999·Biochemical and Biophysical Research Communications·H HinoK Yoshizato
Nov 1, 1995·Critical Reviews in Oncology/hematology·N ItoT Shirai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.