An evaluation of crude palm oil (CPO) and tocotrienol rich fraction (TRF) of palm oil as percutaneous permeation enhancers using full-thickness human skin

Pharmaceutical Development and Technology
Inderjeet SinghAndrew Morris

Abstract

The drawbacks associated with chemical skin permeation enhancers such as skin irritation and toxicity necessitated the research to focus on potential permeation enhancers with a perceived lower toxicity. Crude palm oil (CPO) is obtained by direct compression of the mesocarp of the fruit of the oil palm belonging to the genus Elaeis. In this research, CPO and tocotrienol-rich fraction (TRF) of palm oil were evaluated for the first time as skin permeation enhancers using full-thickness human skin. The in vitro permeation experiments were conducted using excised human skin mounted in static upright 'Franz-type' diffusion cells. The drugs selected to evaluate the enhancing effects of these palm oil derivatives were 5-fluorouracil, lidocaine and ibuprofen: compounds covering a wide range of Log p values. It was demonstrated that CPO and TRF were capable of enhancing the percutaneous permeation of drugs across full-thickness human skin in vitro. Both TRF and CPO were shown to significantly enhance the permeation of ibuprofen with flux values of 30.6 µg/cm2 h and 23.0 µg/cm2 h respectively, compared to the control with a flux of 16.2 µg/cm2 h. The outcome of this research opens further scope for investigation on the transdermal penetr...Continue Reading

References

Apr 1, 1991·The American Journal of Clinical Nutrition·A A QureshiD M Peterson
Dec 1, 1974·Circulation·K A CollinsworthD C Harrison
Sep 2, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Jones, J Leroux
Sep 10, 1999·Clinical Biochemistry·A TheriaultK Adeli
Jun 27, 2000·Environmental Toxicology and Pharmacology·P SartorelliF Williams
Dec 7, 2000·Progress in Lipid Research·R SambanthamurthiY Tan
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Henry FarrarMichael Gill
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alf LamprechtYoshiaki Kawashima
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Apr 15, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ibrahim A Alsarra, Mohammed N Alarifi
May 18, 2007·Molecular Aspects of Medicine·Chandan K SenSashwati Roy
Dec 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ligang ZhaoYanyan Zhao
Oct 11, 2008·International Journal of Pharmaceutics·Andrew P MorrisCharles M Heard
Jan 10, 2009·Journal of Materials Science. Materials in Medicine·Raje Chouhan, A K Bajpai
Jan 27, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zih-Rou HuangJia-You Fang
Dec 17, 2009·Journal of Endodontics·María Teresa Arias-MolizPilar Baca
Aug 11, 2010·Biochemical Pharmacology·Bharat B AggarwalRamaswamy Kannappan
Sep 18, 2010·Journal of the American College of Nutrition·Chandan K SenSavita Khanna
Nov 10, 2010·Nucleic Acids Research·Craig KnoxDavid S Wishart
Sep 6, 2012·Nutrition Reviews·Rebecca S Y Wong, Ammu K Radhakrishnan
Mar 7, 2013·International Journal of Pharmaceutics·Majella E Lane
Feb 13, 2015·Current Drug Delivery·Rajesh Sreedharan Nair, Sujith Nair
Oct 30, 2015·Pharmaceutical Development and Technology·Khalid M El-SayAhmed S Zidan
Nov 27, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Prasanna Raju YTejeswari N

❮ Previous
Next ❯

Citations

Dec 5, 2020·Pharmaceutical Development and Technology·Rajesh Sreedharan NairAndrew P Morris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.