An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity

Clinical Biochemistry
Ozen OzensoyMalcolm Lyon

Abstract

The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether these erythrocyte enzyme activities are altered in patients who have carcinoma. Cytosolic erythrocyte enzyme activities were measured in 108 cancer patients presenting with carcinoma at one of variable sites, prior to clinical treatment. These were compared with an age- and sex-matched control group of 31 healthy volunteers. Mean (+/-SD) catalase activities did not differ significantly, i.e. 0.0035 (+/-0.0015) EU/ml in carcinoma patients vs. 0.0031 (+/-0.00075) EU/ml in controls. However, mean carbonic anhydrase activities of 204 (+/-91) EU/ml in the carcinoma patients were significantly higher than the 158 (+/-35) EU/ml in controls (P value of 0.0065). Cytosolic erythrocyte carbonic anhydrase levels may warrant further investigation as a potential peripheral marker in cancer.

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Citations

May 9, 2012·European Journal of Internal Medicine·Aymelek GönençBolkan Şimşek
Apr 29, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Fatma Pelin CengizOzen Ozensoy Guler
Oct 11, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Asif Husain, Diwakar Madhesia
Jul 31, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Ozen OzensoyFeray Kockar
Aug 21, 2010·European Journal of Medicinal Chemistry·Rahmi KasımoğullarıBaşak Gökçe

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