An evaluation of neutralizing antibody induction during treatment of glabellar lines with a new US formulation of botulinum neurotoxin type A

Aesthetic Surgery Journal
Ira Lawrence, Ronald Moy

Abstract

The induction of neutralizing antibodies during the aesthetic application of botulinum neurotoxin type A is rare, but of potential clinical concern. Phase III studies of a new US formulation of botulinum neurotoxin type A, Dysport (BoNTA-ABO [abobotulinumtoxinA]; Medicis Aesthetics, Scottsdale, AZ), have not identified any cases of neutralizing antibody formation during the treatment of glabellar lines in patients who received up to nine treatments. To provide an in-depth analysis of the potential for induction of neutralizing antibodies in the study population enrolled in phase III trials of BoNTA-ABO in the treatment of glabellar lines. First and last available serum samples from patients in the BoNTA-ABO Glabellar Lines Development Program were screened for BoNTA-ABO antibodies with a radioimmunoprecipitation assay (RIPA), followed by a confirmatory competitive assay (RIPA-C). Confirmed RIPA-C-positive samples were further evaluated for the presence of neutralizing antibodies using a mouse protection assay (MPA), a highly specific bioassay for neutralizing antibodies. We conducted safety and efficacy evaluations, including day 30 responder rate (a rating of no or mild glabellar lines) and duration of response in the last tre...Continue Reading

References

Sep 1, 1995·Neurology·J Jankovic, K Schwartz
Apr 21, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P A HannaA Vincent
Mar 18, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·M Zouhair Atassi
Jun 23, 2005·International Ophthalmology Clinics·K Roger Aoki
Jan 19, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D Dressler, M Hallett
May 23, 2006·Ophthalmic Plastic and Reconstructive Surgery·Gary Borodic
Feb 24, 2007·Facial Plastic Surgery Clinics of North America·Gary Borodic
Jun 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Mitchell F BrinUNKNOWN CD-017 BoNTA Study Group
Mar 18, 2009·Archives of Facial Plastic Surgery·Ronald MoyUNKNOWN Reloxin Investigational Group
Jun 25, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Fredric BrandtBarbara Huber
Jul 13, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joel SchlessingerNaomi Mendelsohn

❮ Previous
Next ❯

Citations

Sep 26, 2012·Journal of Neural Transmission·Markus NaumannConor J Gallagher
Mar 15, 2012·Current Treatment Options in Neurology·Amit BatlaKailash P Bhatia
Jan 1, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joel SchlessingerUNKNOWN Dysport Study Group
Dec 14, 2011·Clinical Interventions in Aging·Gabriele Stengel, Eva Kristina Bee
Jul 16, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Daniela HartmannGerd G Gauglitz
Apr 8, 2017·Aesthetic Surgery Journal·Mark NestorAndy Pickett
Apr 8, 2017·Aesthetic Surgery Journal·Joel L Cohen, Nicolo Scuderi
Jan 20, 2011·The International Journal of Neuroscience·Andy Pickett, Raymond L Rosales
Oct 1, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Matthias ImhofUNKNOWN German Society for Dermatology
Apr 7, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A PatilM Goldust
Jul 25, 2021·Aesthetic Surgery Journal·Mayra IanhezHélio Amante Miot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.