An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders

Neuroscience Letters
Shinji MatsunagaNakao Iwata

Abstract

Disturbances of the circadian rhythm are involved in the pathophysiology of bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD). Specifically, because clock gene dysfunction is good candidate for enhancing the susceptibility to these psychiatric disorders, we selected two circadian rhythm-related genes (CSNK1D and CSNK1E) and investigated genetic associations of the genes with these three disorders. None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. To confirm these findings, we analyzed an independent dataset (maximum N=3815) but found a lack of association (P=0.63 for rs2075984 and P=0.61 for rs6502097). The final meta-analysis showed no association between these SNPs with SCZ (P=0.21) and BD (P=0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.

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Citations

Aug 13, 2013·PloS One·Gerben van OoijenAndrew J Millar
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Related Concepts

Diagnosis, Psychiatric
Genetic Markers
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Casein Kinase Idelta
Casein Kinase Iepsilon
Mental Disorders
Bipolar Disorder
Circadian Rhythms
Mental Depression

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