An evaluation of repeat stool testing for Clostridium difficile infection by polymerase chain reaction

Journal of Clinical Gastroenterology
Sahil KhannaLarry M Baddour

Abstract

To evaluate the yield of repeat stool polymerase chain reaction (PCR) testing in patients with suspected Clostridium difficile infection (CDI). CDI is a major challenge in health care due to its frequent occurrence and high associated costs. Enzyme immunoassay and PCR are commonly performed diagnostic tests for CDI. Our microbiology laboratory database was queried from January 1, 2008 to June 30, 2010 for all patients who underwent PCR stool testing for suspected CDI. Data collected included age, sex, number of stool tests performed within a 14-day period after the first test, and location of patient (inpatient vs. outpatient). Analyses were performed using JMP version 9.0.1. PCR testing was performed in 15,515 patients. The median age was 58.3 years (range, 10 d to 104.3 y) and 46.2% of patients were women. Repeat testing was infrequent; 87.3% of patients had testing performed only once in a 14-day period. Increased age, male sex, and inpatient location were predictors of repeat testing. The median time between an initial test and the first repeat test was 5 days. After an initial negative test, the percentage of patients having a subsequent positive test was low (2.7% in 7 d and 3.2% in 14 d). The percentage of repeat tests t...Continue Reading

References

Mar 9, 1978·The New England Journal of Medicine·J G BartlettA B Onderdonk
Aug 1, 1995·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·D N GerdingJ Silva
Apr 15, 2000·Diagnostic Microbiology and Infectious Disease·W E AldeenK C Carroll
Feb 1, 2002·The New England Journal of Medicine·John G Bartlett
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lance R PetersonKaren L Kaul
Sep 12, 2008·Journal of Clinical Microbiology·Elisabeth AichingerRobin Patel
Oct 11, 2008·Journal of Clinical Microbiology·Diana M Cardona, Kenneth H Rand
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Apr 16, 2009·The American Journal of Gastroenterology·Hashim NematGisele Wolf-Klein
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Becky A MillerDeverick J Anderson
Apr 8, 2011·The Medical Journal of Australia·Allen C ChengUNKNOWN Australasian Society for Infections Diseases
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna M Kufelnicka, Thomas J Kirn

❮ Previous
Next ❯

Citations

Jul 21, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J L LeslieC R Polage
Feb 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sahil KhannaDarrell S Pardi
May 25, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Raina ShivashankarDarrell S Pardi
Nov 7, 2012·Mayo Clinic Proceedings·Sahil Khanna, Darrell S Pardi
Nov 18, 2015·Der Internist·A StallmachA W Lohse
Oct 15, 2013·Journal of Gastroenterology and Hepatology·Lawrence R SchillerJoseph H Sellin
Jul 22, 2014·Alimentary Pharmacology & Therapeutics·R ShivashankarD S Pardi
May 1, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jing WenAshwin N Ananthakrishnan
May 26, 2015·Clinics in Laboratory Medicine·Peter H Gilligan
Mar 4, 2014·Therapeutic Advances in Gastroenterology·Sahil Khanna, Darrell S Pardi
May 15, 2015·American Journal of Clinical Pathology·Sol del Mar AldreteColleen S Kraft
Aug 15, 2014·Journal of Clinical Microbiology·Daniel A GreenPhyllis Della-Latta
Jan 9, 2015·Clinical Microbiology Reviews·Romney M Humphries, Andrea J Linscott
Dec 19, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J J HirvonenS Boisset
May 28, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Masako MizusawaClare Rock
Aug 23, 2019·BMJ : British Medical Journal·Benoit GueryFrédéric Barbut
Dec 21, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Raseen Tariq, Sahil Khanna
Nov 26, 2014·International Journal of Surgical Pathology·Simon Byrns, Laura A Canterbury
Jul 12, 2017·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Arjun K VenkateshIan Schwartz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Fred A ZarMelinda B Davis
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Kathleen M MullaneSherwood L Gorbach
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Shigeki FujitaniA Rekha Murthy
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Stuart H CohenInfectious Diseases Society of America
© 2022 Meta ULC. All rights reserved