An evaluation of the coronary constriction following propranolol

European Journal of Pharmacology
J M Downey

Abstract

This study attempts to determine whether a direct coronary vasoconstriction follows beta blockade with propranolol. Coronary blood flow was varied with the aid of a pump. When myocardial contractile force was plotted as a function of coronary blood flow a characteristic biphasic curve resulted. Autoperfusion without the pump resulted in a flow rate which fell on the knee of that curve. Any direct vasomotion therefore should shift that autoperfused flow rate off of that knee. When propranolol was given intravenously at 0.5 mg/kg a new contractile force--flow curve resulted but the autoperfused coronary blood flow remained at the knee of the curve. Since these data indicate that coronary flow fell precisely in proportion to myocardial metabolism it is concluded that all coronary vasoconstriction following propranolol is secondary to changes in metabolism.

References

Mar 1, 1966·British Journal of Pharmacology and Chemotherapy·P G GaalG Ross
Jun 1, 1970·British Journal of Pharmacology·J R Parratt, R M Wadsworth
Jul 1, 1966·American Heart Journal·J F MurrayE Rapaport
Jan 1, 1967·American Heart Journal·J R Parratt
Apr 1, 1970·Cardiovascular Research·B Pitt, P Craven
Oct 1, 1970·Cardiovascular Research·A J MossJ Sentman
Sep 1, 1966·The American Journal of Cardiology·S WolfsonR Gorlin
Feb 1, 1967·Circulation Research·E O Feigl

Citations

Jan 1, 1981·The American Journal of Cardiology·S GuntherW Grossman
Apr 1, 1981·American Heart Journal·D O Williams
Sep 1, 1980·Clinical Endocrinology·J D Nabarro
Nov 1, 1985·Neuropathology and Applied Neurobiology·A M McNicol
Nov 1, 1983·Clinical Endocrinology·J P Thomas, S H Richards

Related Concepts

Metazoa
Diastolic Blood Pressure
Coronary Circulation
Canis familiaris
Hemodynamics
Inotropism
Rexigen
Vascular Constriction (Function)

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