An evaluation of the effect of lidocaine in experimental focal cerebral ischemia

Stroke; a Journal of Cerebral Circulation
M T ShokunbiP Floyd

Abstract

In order to determine the effect of lidocaine in focal cerebral ischemia, the left middle cerebral artery was transorbitally occluded in twenty cats. Eleven received lidocaine hydrochloride intravenously. The infusion was begun half an hour prior to clip occlusion and the rate was adjusted to maintain an isoelectric EEG. Nine cats served as controls, receiving an equivalent volume of 5% dextrose 0.2% saline. Thirteen animals (7 lidocaine-treated and 6 control) were sacrificed after six hours of left middle cerebral artery occlusion without reperfusion. In the remaining seven cats, the vessel was occluded for four hours prior to sacrifice. Ischemic neuronal alteration was assessed by both histochemical (2'3'5' triphenyl-2H-tetrazolium hydrochloride reaction) and histological examination. With both durations of ischemia, there was no significant difference in the extent and severity of neuronal alterations between the lidocaine-treated and control groups of animals.

Associated Clinical Trials

References

Jan 1, 1978·Stroke; a Journal of Cerebral Circulation·J R Little
Jun 1, 1975·Anesthesiology·R H Haschke, B R Fink
Jun 1, 1973·Electroencephalography and Clinical Neurophysiology·R M Julien
Feb 1, 1984·Journal of Neurosurgery·D E EvansM E Bradley
Sep 1, 1956·Anesthesiology·I C GEDDES, J H QUASTEL
Jul 1, 1957·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M NACHLASA M SELIGMAN

❮ Previous
Next ❯

Citations

Sep 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A W GelbA Rassi-Neto
Jul 1, 1989·Surgical Neurology·J I AusmanG Balakrishnan
Sep 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·L DíazG Bustos
Sep 1, 1988·Epilepsia·J PascualJ Berciano
Jan 24, 2009·Stroke; a Journal of Cerebral Circulation·Joseph P MathewUNKNOWN Neurologic Outcome Research Group (NORG) of the Duke Heart Center
Jan 1, 1989·Journal of Neurosurgery·D E EvansE T Flynn
Jun 1, 1990·Stroke; a Journal of Cerebral Circulation·N RasoolE H Rubinstein
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·A J DutkaJ M Hallenbeck
Sep 1, 1991·Stroke; a Journal of Cerebral Circulation·N MatsumiyaR J Traystman
Jan 1, 1990·Stroke; a Journal of Cerebral Circulation·M T ShokunbiD J Miller
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·G SutherlandA A Sima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.