An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial

Respiratory Research
Marzie ZilaeeAtaollah Ghadiri

Abstract

Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Saffron has anti-inflammatory effects and may has beneficial effects on asthma. The present study was intended to survey the effects of saffron supplementation on blood pressure, lipid profiles, basophils, eosinophils and clinical symptoms in patients with allergic asthma. Our study was a clinical trial. Subjects (N = 80, 32 women and 48 men, 41.25 ± 9.87 years old) with mild and moderate allergic asthma were randomized into two groups: the intervention group who received two capsules of saffron (100 mg/d), and the control group who received two capsules of placebo for 8 weeks. SPSS software (version 16.0) was used for the data analysis. Saffron improved the frequency of clinical symptoms of the patients (i.e., frequency of the shortness of breath during the day and night time, use of salbutamol spray, waking up due to asthma symptoms and activity limitation) in comparison to the placebo (p < 0.001). Besides, asthma severity decreased almost significantly in the saffron group (p = 0.07). It was also found that saffron, in comparison with the placebo, significantly reduced the systolic and diastolic blood pressure, triglycerides and l...Continue Reading

References

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Citations

Feb 6, 2020·Archives of Physiology and Biochemistry·Babak RoshanravanTahereh Farkhondeh
Nov 19, 2019·Frontiers in Pharmacology·Peeraphong LertnimitphunHongxi Xu
Jun 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad Reza KhazdairMohammad Hossein Boskabady
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Azza A AttiaNahla S El-Shenawy
Jun 8, 2021·Frontiers in Immunology·Peeraphong LertnimitphunHongxi Xu
Jul 11, 2021·Cell Biochemistry and Biophysics·Patrick J OliverNarasimham L Parinandi
Sep 18, 2021·Phytotherapy Research : PTR·Neda Roshanravan, Samad Ghaffari
Dec 29, 2021·Critical Reviews in Food Science and Nutrition·Ju ShenHaixiang Wang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

modified
GINA
SPSS

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