An evaluation of the efficacy of fluorescein, rose bengal, lissamine green, and a new dye mixture for ocular surface staining

Eye & Contact Lens
Donald R KorbCaroline A Blackie

Abstract

Sodium fluorescein is considered the premier dye for corneal staining and, similarly, rose bengal (RB) for conjunctival staining. A mixture of 1% fluorescein and 1% rose bengal has been reported as advantageous in daily practice. Mixtures of lissamine green with other ocular stains have not been reported. The purposes of this study were to review the clinical staining characteristics of fluorescein, rose bengal, and lissamine green in controlled dose and concentration and determine whether optimal staining of the cornea and bulbar conjunctiva are possible by using dye mixtures. Sixteen 10-microL solutions of fluorescein, rose bengal, lissamine green, and their mixtures were evaluated. Fourteen subjects with a diagnosis of dry eye were tested for staining with various combinations of the dyes. Examination of staining was made by using standard clinical practices. A mixture of 2% fluorescein and 1% rose bengal was the most efficacious staining mixture for the cornea and conjunctiva, but moderate to marked discomfort was reported. The mixture of 2% fluorescein and 1% lissamine green did not result in discomfort and provided optimal corneal and conjunctival staining with only slightly less efficacy than 2% fluorescein and 1% rose b...Continue Reading

References

Jul 1, 1992·Archives of Ophthalmology·R P Feenstra, S C Tseng
Jan 1, 1994·International Ophthalmology Clinics·S C Tseng
Jun 23, 1998·Advances in Experimental Medicine and Biology·V M FinnemoreJ P Herman
Dec 23, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Michael J DoughtyNorman F Button
Dec 2, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michel Guillon, Cecile Maissa
Nov 2, 2006·Cornea·David A BerntsenJason J Nichols

❮ Previous
Next ❯

Citations

Aug 10, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michael J Doughty
Mar 19, 2013·Retina·Hee Yoon ChoSe Woong Kang
Nov 13, 2009·Cornea·Nathan EfronNicola Pritchard
Jul 22, 2014·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michael J Doughty
Dec 3, 2014·Progress in Retinal and Eye Research·A J BronF V Bright
Dec 29, 2012·Eye & Contact Lens·Meng C Lin, Thao N Yeh
Oct 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Monica BerryPaul J Murphy
Aug 24, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Heiko PultE Marx
Aug 13, 2015·Journal of Functional Biomaterials·Masatoshi HirayamaTakashi Tsuji
Sep 21, 2013·Current Eye Research·John L BradleyRoderick J Fullard
May 17, 2011·Archivos de la Sociedad Española de Oftalmología·L C Figueroa-OrtizJ García-Campos
Jun 26, 2012·Survey of Ophthalmology·Samantha McGinnigleFrank Eperjesi
Mar 17, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·M GuillonS Ho
Jul 15, 2009·Clinical & Experimental Ophthalmology·Nathan EfronNicola Pritchard
Oct 12, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan Efron
May 29, 2013·Journal of Biophotonics·Mathew BartonAntonio Lauto
Aug 11, 2015·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Youngsub EomJong Suk Song
Apr 21, 2016·Progress in Retinal and Eye Research·Nathan EfronTawnya Wilson
Jun 10, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Morris ArkColin R Dunstan
Jul 9, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Marc-Matthias SchulzeUNKNOWN Performance of Contact Lens Solutions Study Group
Aug 21, 2016·American Journal of Ophthalmology·Zhihong DengJin Zhou
May 23, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Waleed M AlghamdiEric B Papas
Oct 20, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jaya Sowjanya SiddireddyMark Willcox
Feb 7, 2020·Veterinary Ophthalmology·Thiago Alegre Coelho FerreiraFabiano Montiani-Ferreira
Sep 6, 2013·Issues in Mental Health Nursing·Kourosh AminiMehrdad Eftekhar
Mar 22, 2019·Scientific Reports·Seung Ho LeeYoung Bin Choy
May 19, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Chris W LievensMarta Vianya-Estopa
Oct 30, 2020·Clinical Ophthalmology·Christopher W LievensMarta Vianya-Estopa
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Min FangJianhua Wang
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·James S WolffsohnFiona Stapleton
Nov 25, 2018·Progress in Retinal and Eye Research·Christophe BaudouinMarc Labetoulle
Aug 18, 2021·Translational Vision Science & Technology·Trefford SimpsonSara Butterworth Connell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.